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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 60 - 70 (11page)
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초록· 키워드
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Background/Aims: Fibroblast growth factor signaling is involved in hepatocarcinogenesis. The aim of this study wasto determine the fibroblast growth factor receptor (FGFR) isotype expression in hepatocellular carcinoma (HCC) andneighboring nonneoplastic liver tissue, and elucidate its prognostic implications.
Methods: Immunohistochemical staining of FGFR1, -2, -3, and -4 was performed in the HCCs and paired neighboringnonneoplastic liver tissue of 870 HCC patients who underwent hepatic resection. Of these, clinical data for 153 patientswho underwent curative resection as a primary therapy were reviewed, and the relationship between FGFR isotypeexpression and overall survival was evaluated (development set). This association was also validated in 73 independentsamples (validation set) by Western blot analysis.
Results: FGFR1, -2, -3, and -4 were expressed in 5.3%, 11.1%, 3.8%, and 52.7% of HCCs, respectively. Among thedevelopment set of 153 patients, FGFR2 positivity in HCC was associated with a significantly shorter overall survival (5-yearsurvival rate, 35.3% vs. 61.8%; P =0.02). FGFR2 expression in HCC was an independent predictor of a poor postsurgicalprognosis (hazard ratio, 2.10; P=0.02) in the development set. However, the corresponding findings were not statisticallysignificant in the validation set.
Conclusions: FGFR2 expression in HCC could be a prognostic indicator of postsurgical survival. (Clin Mol Hepatol2015;21:60-70)
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참고문헌 (24)
참고문헌 신청
Adnane J / 1991 / Bek and flg, two receptors to members of the fgf family, are amplified in subsets of human breast cancers / Oncogene 6 : 659 ~ 663
Amann T / 2010 / Reduced expression of fibroblast growth factor receptor 2iiib in hepatocellular carcinoma induces a more aggressive growth / Am J Pathol 176 : 1433 ~ 1442
Gauglhofer C / 2011 / Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis / Hepatology 53 : 854
Grose R / 2005 / Fibroblast growth factor signaling in tumorigenesis / Cytokine Growth Factor Rev 16 : 179 ~ 186
Harimoto N / 2010 / The significance of fibroblast growth factor receptor 2 expression in differentiation of hepatocellular carcinoma / Oncology 78 : 361 ~ 368
Amann T / 2010 / Reduced expression of fibroblast growth factor receptor 2iiib in hepatocellular carcinoma induces a more aggressive growth / Am J Pathol 176 : 1433 ~ 1442
Gauglhofer C / 2011 / Up-regulation of the fibroblast growth factor 8 subfamily in human hepatocellular carcinoma for cell survival and neoangiogenesis / Hepatology 53 : 854
Grose R / 2005 / Fibroblast growth factor signaling in tumorigenesis / Cytokine Growth Factor Rev 16 : 179 ~ 186
Harimoto N / 2010 / The significance of fibroblast growth factor receptor 2 expression in differentiation of hepatocellular carcinoma / Oncology 78 : 361 ~ 368
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