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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 250 - 258 (9page)
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초록· 키워드
오류제보하기
Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by selective and progressive loss of dopaminergic neurons. Genetic and environmental risk factors are associated with this disease. The genetic factors are composed of approximately 20 genes, such as SNCA, parkin, PTEN-induced kinase1 (pink1), leucine-rich repeat kinase 2 (LRRK2), ATP13A2, MAPT, VPS35, and DJ-1, whereas the environmental factors consist of oxidative stress-induced toxins such as 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP), rotenone, and paraquat. The analyses of their functions and mechanisms have provided important insights into the disease process, which has demonstrated that these factors cause oxidative damage and mitochondrial dysfunction. The most invaluable studies have been performed using disease model organisms, such as mice, fruit flies, and worms. Among them, Drosophila melanogaster has emerged as an excellent model organism to study both environmental and genetic factors and provide insights to the pathways relevant for PD pathogenesis, facilitating development of therapeutic strategies. In this review, we have focused on the fly model organism to summarize recent progress, including pathogenesis, neuroprotective compounds, and newer approaches.
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등록된 정보가 없습니다.
참고문헌 (99)
참고문헌 신청
Forno LS / 1996 / Neuropathology of Parkinson's disease / J Neuropathol Exp Neurol 55:259~272
Whitton P / 2007 / Inflammation as a causative factor in the aetiology of Parkinson's disease / Br J Pharmacol 150:963~976
Polymeropoulos MH / 1997 / Mutation in the α-synuclein gene identified in families with Parkinson's disease / Science 276:2045~2047
Singleton A / 2003 / α-Synuclein locus triplication causes Parkinson's disease / Science 302:841~841
Zimprich A / 2004 / Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology / Neuron 44:601~607
Whitton P / 2007 / Inflammation as a causative factor in the aetiology of Parkinson's disease / Br J Pharmacol 150:963~976
Polymeropoulos MH / 1997 / Mutation in the α-synuclein gene identified in families with Parkinson's disease / Science 276:2045~2047
Singleton A / 2003 / α-Synuclein locus triplication causes Parkinson's disease / Science 302:841~841
Zimprich A / 2004 / Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology / Neuron 44:601~607
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