지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
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- 학술저널
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- 2015.1
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Parkinson’s disease (PD) is an age-related progressive neurodegenerative disease associated with selective loss of dopaminergic neurons. The characteristic hallmark of the disease is intracytoplasmic proteinacious inclusion bodies called Lewy bodies, primarily consisting of a presynaptic protein α-synuclein. Oxidative stress-mediated damage to macromolecules have been shown to occur frequently in PD. Oxidative damage to DNA in the form of oxidized guanine (8-oxodG) accumulates in both the mitochondrial and nuclear DNA of dopaminergic neurons of the substantia nigra in PD. 8-oxodG-mediated transcriptional mutagenesis has been shown to have the potential to alter phenotype of cells through production of mutant pool of proteins. This review comprehensively summarizes the role of oxidative stress-mediated damage incurred during neurodegeneration, and highlights the scope of transcriptional mutagenesis event in leading to α-synuclein aggregation as seen in PD.
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참고문헌 (25)
참고문헌 신청
Alam ZI / 1997 / A generalised increase in protein carbonyls in the brain in Parkinson's but not incidental Lewy body disease / J Neurochem 69 : 1326 ~ 1329
Alam ZI / 1997 / Oxidative DNA damage in the parkinsonian brain : an apparent selective increase in 8-hydroxyguanine levels in substantia nigra / J Neurochem 69 : 1196 ~ 1203
Andersen JK / 2004 / Oxidative stress in neurodegeneration: cause or consequence? / Nat Med 10 : S18 ~ S25
Aoyama K / 2000 / Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases /
Baynes JW. / 1991 / Role of oxidative stress in development of complications in diabetes / Diabetes 40 : 405 ~ 412
Alam ZI / 1997 / Oxidative DNA damage in the parkinsonian brain : an apparent selective increase in 8-hydroxyguanine levels in substantia nigra / J Neurochem 69 : 1196 ~ 1203
Andersen JK / 2004 / Oxidative stress in neurodegeneration: cause or consequence? / Nat Med 10 : S18 ~ S25
Aoyama K / 2000 / Nitration of manganese superoxide dismutase in cerebrospinal fluids is a marker for peroxynitrite-mediated oxidative stress in neurodegenerative diseases /
Baynes JW. / 1991 / Role of oxidative stress in development of complications in diabetes / Diabetes 40 : 405 ~ 412
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