지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 243 - 248 (6page)
이용수
초록· 키워드
오류제보하기
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson’s disease (PD). As such, functions and dysfunctions of LRRK2 in PD have been the subject of extensive investigation. In addition to PD, increasing evidence is suggesting that LRRK2 is associated with a wide range of diseases. Genome-wide association studies have implicated LRRK2 in Crohn’s disease (CD) and leprosy, and the carriers with pathogenic mutations of LRRK2 show increased risk to develop particular types of cancer. LRRK2 mutations are rarely found in Alzheimer’s disease (AD), but LRRK2 might play a part in tauopathies. The association of LRRK2 with the pathogenesis of apparently unrelated diseases remains enigmatic, but it might be related to the yet unknown diverse functions of LRRK2. Here, we reviewed current knowledge on the link between LRRK2 and several diseases, including PD, AD, CD, leprosy, and cancer, and discussed the possibility of targeting LRRK2 in such diseases.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Bialik S / 2006 / The death-associated protein kinases: structure, function, and beyond / Annu Rev Biochem 75 : 189 ~ 210
Bialik S / 2010 / Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy / Curr Opin Cell Biol 22 : 199 ~ 205
Chuang YT / 2008 / The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation / J Immunol 180 : 3238 ~ 3249
Chuang YT / 2011 / Tumor suppressor death-associated protein kinase is required for full IL-1beta production / Blood 117 : 960 ~ 970
Dzamko N / 2012 / The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling / PLoS One 7 : e3913
Bialik S / 2010 / Lethal weapons: DAP-kinase, autophagy and cell death: DAP-kinase regulates autophagy / Curr Opin Cell Biol 22 : 199 ~ 205
Chuang YT / 2008 / The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappa B activation / J Immunol 180 : 3238 ~ 3249
Chuang YT / 2011 / Tumor suppressor death-associated protein kinase is required for full IL-1beta production / Blood 117 : 960 ~ 970
Dzamko N / 2012 / The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling / PLoS One 7 : e3913
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
LRRK2 and membrane trafficking: nexus of Parkinson's disease
BMB Reports
2019 .01
-
Disease model organism for Parkinson disease: Drosophila melanogaster
BMB Reports
2019 .01
-
다중 커널을 이용한 파킨슨 환자로부터 보행 동결 진행까지의 페널티 콕스 회귀 분석
보건정보통계학회지
2023 .02
-
A Transfer Learning Approach on Neuropathologic Features for Alzheimer's Early Detection using MRI Images
INTERNATIONAL CONFERENCE ON FUTURE INFORMATION & COMMUNICATION ENGINEERING
2023 .01
-
PD에게 5G란 무엇인가?
방송과 미디어
2019 .07
-
Precise control of mitophagy through ubiquitin proteasome system and deubiquitin proteases and their dysfunction in Parkinson’s disease
BMB Reports
2021 .12
-
A Machine Learning Approach to Discriminate the Parkinson`s disease from Other Neurological Diseases using Different Feature Selection Techniques Based on Gait Parameters
INTERNATIONAL CONFERENCE ON FUTURE INFORMATION & COMMUNICATION ENGINEERING
2018 .06
-
Whole-genome sequencing reveals an association between small genomic deletions and an increased risk of developing Parkinson’s disease
Experimental and Molecular Medicine
2023 .03
-
파킨슨병 조기 진단을 위한 안드로이드 기반의 앱 개발
한국인터넷방송통신학회 논문지
2019 .01
-
The pivotal role of the NLRC4 inflammasome in neuroinflammation after intracerebral hemorrhage in rats
Experimental and Molecular Medicine
2021 .11
-
Amorphous Co3O4-Decorated Pd as an Efficient Electrocatalyst for Methanol Oxidation
NANO
2017 .01
-
Exosomal PD-L1 promotes tumor growth through immune escape in non-small cell lung cancer
Experimental and Molecular Medicine
2019 .01
-
Diagnosing Parkinson's Disease Using Movement Signal Mapping by Neural Network and Classifier Modulation
[ETRI] ETRI Journal
2017 .12
-
An Implementation of Effective CNN Model for AD Detection
스마트미디어저널
2024 .06
-
Synapses in neurodegenerative diseases
BMB Reports
2017 .01
-
The Therapeutic Potential of Stem Cells and Progenitor Cells for the Treatment of Parkinson’s Disease
조직공학과 재생의학
2016 .01
-
Strict Anaerobic Microbiota to Clinical Application
한국생물공학회 학술대회
2021 .04
-
Detection of Parkinson’s Disease using 3D Convolutional Neural Networks
한국정보통신학회 종합학술대회 논문집
2020 .07
-
Patient-specific pluripotent stem cell-based Parkinson’s disease models showing endogenous alpha-synuclein aggregation
BMB Reports
2019 .01
-
Understanding of Epigenetic Regulations in Alzheimer’s Disease
한국생물공학회 학술대회
2015 .10
이 논문의 저자 정보
최근 본 자료
댓글(0)
0