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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 1 - 9 (9page)
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The effects of capsaicin (CAP), a transient receptor potential vanilloid subtype 1 (TRPV1) agonist, were determined on nigrostriatal dopamine (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson’s disease (PD). The results showed that TRPV1 activation by CAP rescued nigrostriatal DA neurons, enhanced striatal DA functions and improved behavioral recovery in MPTP-treated mice. CAP neuroprotection was associated with reduced expression of proinflammatory cytokines (tumor necrosis factor-α and interleukin-1β) and reactive oxygen species/reactive nitrogen species from activated microglia-derived NADPH oxidase, inducible nitric oxide synthase or reactive astrocyte-derived myeloidperoxidase. These beneficial effects of CAP were reversed by treatment with the TRPV1 antagonists capsazepine and iodo-resiniferatoxin, indicating TRPV1 involvement. This study demonstrates that TRPV1 activation by CAP protects nigrostriatal DA neurons via inhibition of glial activation-mediated oxidative stress and neuroinflammation in the MPTP mouse model of PD. These results suggest that CAP and its analogs may be beneficial therapeutic agents for the treatment of PD and other neurodegenerative disorders that are associated with neuroinflammation and glial activation-derived oxidative damage.
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참고문헌 (22)
참고문헌 신청
Choi DK / 2005 / Ablation of the inflammatory enzyme myeloperoxidase mitigates features of Parkinson’s disease in mice / J Neurosci 25 : 6594 ~ 6600
Chung YC / 2010 / Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson'
Chung YC / 2011 / Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation / J Immunol 187 : 65
Dauer W / 2003 / Parkinson's disease : mechanisms and models / Neuron 39 : 889 ~ 909
Di Marzo V / 2001 / Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues / Eur J Pharmacol 420 : 123 ~ 131
Chung YC / 2010 / Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson'
Chung YC / 2011 / Cannabinoid receptor type 1 protects nigrostriatal dopaminergic neurons against MPTP neurotoxicity by inhibiting microglial activation / J Immunol 187 : 65
Dauer W / 2003 / Parkinson's disease : mechanisms and models / Neuron 39 : 889 ~ 909
Di Marzo V / 2001 / Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues / Eur J Pharmacol 420 : 123 ~ 131
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