지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.4
- 수록면
- 146 - 150 (5page)
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초록· 키워드
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BACKGROUND/OBJECTIVES: Cholecystokinin (CCK), a hormone or neuropeptide, is secreted in response to intraluminal nutrients by enteroendocrine I-cells of the intestine and has important physiological actions related to appetite regulation and satiety. The stimulation on CCK secretion from the intestine is of potential relevance for body weight management. Naringenin (4’,5,7-trihydroxyflavanone) and its glycoside naringin (naringenin 7-rhamnoglucoside) have been reported to have many biological functions. In the current study, we investigated the question of whether naringenin and naringin could stimulate CCK secretion and then examined the mechanisms involved in CCK release.
MATERIALS/METHODS: STC-1 cells were used as a model of enteroendocrine cells. CCK release and changes in intracellular Ca<SUP>2+</SUP> ([Ca<SUP>2+</SUP>]i) were measured after incubation of cells with naringenin and naringin for 1 h.
RESULTS: Naringenin caused significant (P < 0.05) stimulation of CCK secretion, but naringin did not. In addition, regarding the secretory mechanisms, naringenin-induced CCK secretion involved increases in [Ca<SUP>2+</SUP>]i, influx of extracellular Ca<SUP>2+</SUP>, at least in part, and activation of TRP channels, including TRPA1.
CONCLUSION: Findings of this study suggest that naringenin could have a role in appetite regulation and satiety.
MATERIALS/METHODS: STC-1 cells were used as a model of enteroendocrine cells. CCK release and changes in intracellular Ca<SUP>2+</SUP> ([Ca<SUP>2+</SUP>]i) were measured after incubation of cells with naringenin and naringin for 1 h.
RESULTS: Naringenin caused significant (P < 0.05) stimulation of CCK secretion, but naringin did not. In addition, regarding the secretory mechanisms, naringenin-induced CCK secretion involved increases in [Ca<SUP>2+</SUP>]i, influx of extracellular Ca<SUP>2+</SUP>, at least in part, and activation of TRP channels, including TRPA1.
CONCLUSION: Findings of this study suggest that naringenin could have a role in appetite regulation and satiety.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
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