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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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The biological effects of carcinogenic polycyclic aromatic hydrocarbons (cPAHs) includingbenzo[a]pyrene (BaP), dibenzo[a,h]anthracene (DBA), benzo[a]anthracene (BaA), benzo[b]fluoranthene (BbF), benzo[k]fluoranthene (BkF), and indeno[1,2,3-c, d]pyrene (InP) on transcriptomicchanges were determined in the liver of Oryzias latipes. Differentially expressed genes (DEGs)by binary exposure to cPAHs (BaP+BaA, BaP+BbF, BaP+BkF, BaP+DbA, BaP+InP) werescreened by annealing control primers-based polymerase chain reaction followed by sequenceanalysis and BLAST searching. The results showed that four DEGs were commonly expressed bycPAHs and they were identified as ribosomal protein S4, coagulation factor II, elongation factor 1beta, and a predicted protein similar to human immunodeficiency virus type I enhancer bindingprotein 3. This finding suggests that binary exposure to cPAHs interferes protein synthesis requiredfor fundamental liver functions in fish.
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참고문헌 (23)
참고문헌 신청
Adamo RD / 1997 / Bioaccumulation and biomagnification of polycyclic aromatic hydrocarbons in aquatic organisms / Mar. Chem. 56 : 45 ~
Aravindakshan J / 2004 / Consequences of xenoestrogen exposure on male reproductive function in spottail shiners (Notropis hudsonius) / Toxicol. Sci. 78 : 156 ~
Baumard P / 1998 / Concentrations of PAHs (Polycyclic aromatic hydrocarbons) in various marine organisms in relation to those in sediments and to trophic level / Mar. Pollut.
Carlson EA / 2004 / Benzo[a]pyrene-induced immunotoxicity in Japanese medaka (Oryzias latipes), relationship between lymphoid CYP1A activity and humoral immune suppression /
Carr-schmid A / 1999 / Mutations in elongation factor 1, a guanine nucleotide exchange factor, enhance translational fidelity / Mol. Cell. Biol. 19 : 5257 ~
Aravindakshan J / 2004 / Consequences of xenoestrogen exposure on male reproductive function in spottail shiners (Notropis hudsonius) / Toxicol. Sci. 78 : 156 ~
Baumard P / 1998 / Concentrations of PAHs (Polycyclic aromatic hydrocarbons) in various marine organisms in relation to those in sediments and to trophic level / Mar. Pollut.
Carlson EA / 2004 / Benzo[a]pyrene-induced immunotoxicity in Japanese medaka (Oryzias latipes), relationship between lymphoid CYP1A activity and humoral immune suppression /
Carr-schmid A / 1999 / Mutations in elongation factor 1, a guanine nucleotide exchange factor, enhance translational fidelity / Mol. Cell. Biol. 19 : 5257 ~
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