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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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In this study, alterations in whole proteome expression patterns in the head of Japanesemedaka (Oryzias latipes) was investigated following acute or chronic exposure to benzo(a)pyrene (BaP) (25 μg L-1) for 48 hrs and 15 days, respectively. The results showed that 9 and 6protein spots were statistically different, relative to controls, in response to acute and chronic BaPexposure, respectively. In the acute exposure group, 5 spots were upregulated and 4 spots weredownregulated, while in the chronic exposure group, 4 spots were upregulated and 2 spots weredownregulated. Three of these spots were common to both the acute and chronic BaP exposuregroups and were identified using LC-MS/MS followed by database searching. These 3 spots werefound to be associated with structural proteins belonging to the actin and keratin families. Thesedata suggest that acute and chronic exposures to BaP may affect tissue morphology in the head ofJapanese medaka.
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참고문헌 (24)
참고문헌 신청
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Bahk YY / 2004 / Antigens secreted from Mycobacterium tuberculosis: Identification by proteomics approach and test for diagnostic marker / Proteomics 4 : 3299 ~ 3307
Bartsch H / 1996 / DNA adducts in human carcinogenesis: etiological relevance and structure-activity relationship / Mutat. Res 340 : 67 ~ 79
Carlson EA / 2002 / Exposure of Japanese medaka (Oryzias latipes) to benzo[a]pyrene suppresses immune function and host resistance against bacterial challenge / Aquat. Toxico
Carlson EA / 2004 / Benzo[a]pyreneinduced immunotoxicity in Japanese medaka (Oryzias latipes): relationship between lymphoid CYP1A activity and humoral immune suppression / T
Bahk YY / 2004 / Antigens secreted from Mycobacterium tuberculosis: Identification by proteomics approach and test for diagnostic marker / Proteomics 4 : 3299 ~ 3307
Bartsch H / 1996 / DNA adducts in human carcinogenesis: etiological relevance and structure-activity relationship / Mutat. Res 340 : 67 ~ 79
Carlson EA / 2002 / Exposure of Japanese medaka (Oryzias latipes) to benzo[a]pyrene suppresses immune function and host resistance against bacterial challenge / Aquat. Toxico
Carlson EA / 2004 / Benzo[a]pyreneinduced immunotoxicity in Japanese medaka (Oryzias latipes): relationship between lymphoid CYP1A activity and humoral immune suppression / T
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