지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 467 - 477 (11page)
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초록· 키워드
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Objectives: Oxidative stress and DNA damage have been proposed as mechanisms linking pesticide exposure to health effects such as cancer and neurological diseases. We investigated whether protective measures could significantly reduce the levels of biomarkers for oxidative stress and DNA damage in agricultural workers.
Methods: In the present study, the levels of malondialdehyde (MDA) and 8-hydroxy-2’-deoxyguanosine (8OHdG), biomarkers related to oxidative stress and DNA damage, respectively, were analyzed in urine samples collected from agricultural workers in two provinces of Korea (n=60). The influence of wearing personal protective equipment (PPE) and performing protective behaviors on the levels of these two biomarkers was also evaluated.
Results: The median urinary levels of MDA and 8-OHdG were 10.45 nmol/mg creatinine and 14.42 ng/mg creatinine in subjects living in region A, while they were 6.25 nmol/mg creatinine and 24.77 ng/mg creatinine in subjects living in region B, respectively. The levels of MDA and 8-OHdG were higher in male farmers. Farmers wearing greater numbers of PPE and performing more protective behaviors had significantly lower levels of MDA. Greater numbers of protective behaviors was significantly associated with lower levels of 8-OHdG.
Conclusion: The results of the present study indicate that pesticide exposure could induce oxidative stress and DNA damage in agricultural workers, and that protective measures are important for mitigating pesticide exposure.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
/ / United States Environmental Protection Agency
Aktar MW / 2009 / Impact of pesticides use in agriculture: their benefits and hazards / Interdiscip Toxicol 2 (1) : 1 ~ 12
Alavanja MC / 2012 / Occupational pesticide exposures and cancer risk: a review / J Toxicol Environ Health B Crit Rev 15 (4) : 238 ~ 263
Banerjee BD / 1999 / Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers / Toxicol Lett 107 (1-3) : 33 ~ 47
Damalas CA / 2011 / Pesticide exposure, safety issues, and risk assessment indicators / Int J Environ Res Public Health 8 (5) : 1402 ~ 1419
Aktar MW / 2009 / Impact of pesticides use in agriculture: their benefits and hazards / Interdiscip Toxicol 2 (1) : 1 ~ 12
Alavanja MC / 2012 / Occupational pesticide exposures and cancer risk: a review / J Toxicol Environ Health B Crit Rev 15 (4) : 238 ~ 263
Banerjee BD / 1999 / Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers / Toxicol Lett 107 (1-3) : 33 ~ 47
Damalas CA / 2011 / Pesticide exposure, safety issues, and risk assessment indicators / Int J Environ Res Public Health 8 (5) : 1402 ~ 1419
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