지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 616 - 621 (6page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThe aim of this study was to investigate whether cortisol and oxidative stress levels and DNA damage differ between individuals who developed PTSD or not following a sexual trauma.
MethodsaaThe study included 61 children aged between 5 and 17 years who sustained sexual abuse (M/F: 18/43). The patients were divided into two groups: patients with PTSD and patients without PTSD based, based on the results of a structured psychiatric interview (K-SADS-PL and CAPS-CA). Cortisol, glutathione peroxidase (GPx), superoxide dismutase (SOD), coenzyme Q, 8-Hydroxy-2-Deoxyguanosine (8-OHdG) were all evaluated by the ELISA method.
ResultsaaOur evaluation revealed a diagnosis of PTSD in 51% (n=31) of victims. There was no significant difference between the groups with or without PTSD in terms of cortisol, GPx, SOD, coenzyme Q, and 8-OHdG levels. There was no correlation between CAPS scores and GPx, SOD, coenzyme Q, and 8-OHdG levels between patients with or without PTSD. In patients with PTSD, both cortisol and 8-OHdG levels decreased with increasing time after trauma, and there was no significant correlation with cortisol and 8-OHdG levels in patients without PTSD.
ConclusionaaAlthough the present study did not find any difference between the groups in terms of 8-OHdG concentrations, the decreases in both cortisol and 8-OHdG levels with increasing time after trauma is considered to indicate a relationship between cortisol and DNA damage.
목차
등록된 정보가 없습니다.
참고문헌 (33)
참고문헌 신청
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) / American Psychiatric Association
Simmons JG / 2014 / Study protocol: imaging brain development in the Childhood to Adolescence Transition Study (iCATS) / BMC Pediatr 14:115
Feiring C / 1999 / Age and gender differences in children’s and adolescents’ adaptation to sexual abuse / Child Abuse Negl 23:115~128
Maniglio R / 2009 / The impact of child sexual abuse on health: a systematic review of reviews / Clin Psychol Rev 29:647~657
Yehuda R / 2009 / Glucocorticoids and Mood Clinical Manifestations, Risk Factors, and Molecular Mechanisms. Vol 1179 / Wiley-Blackwell :56~69
Simmons JG / 2014 / Study protocol: imaging brain development in the Childhood to Adolescence Transition Study (iCATS) / BMC Pediatr 14:115
Feiring C / 1999 / Age and gender differences in children’s and adolescents’ adaptation to sexual abuse / Child Abuse Negl 23:115~128
Maniglio R / 2009 / The impact of child sexual abuse on health: a systematic review of reviews / Clin Psychol Rev 29:647~657
Yehuda R / 2009 / Glucocorticoids and Mood Clinical Manifestations, Risk Factors, and Molecular Mechanisms. Vol 1179 / Wiley-Blackwell :56~69
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