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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 566 - 570 (5page)
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초록· 키워드
오류제보하기
Exposure to ultraviolet B(UVB) radiation causes skin inflammation such as pigmentation and the induction of cyclooxygenase-2(COX-2) gene expression. In this study, we investigated the effect of natural extracts from Tea, EGb 761 and Korean red ginseng(KRG), on the pigmentation and expression of COX-1 and COX-2 mRNA in UVB-irradiated C57BL/6 mice. Before UVB irradiation, the skin color was significantly showed the lightening effect by topical application of natural compounds (p<.05). In the case of UVB irradiated mice, we observed a decrease in pigmentation by compounds (p<.05). In irradiated skin, COX-1 mRNA expression is not changed following UVB irradiation, but COX-2 gene increases. Also, natural compounds lowered mRNA levels of COX-2. Therefore, these results suggest that COX-2 mRNA increases by UVB irradiation. Also, Tea, EGb 761 and KRG as a topical application may inhibit skin pigmentation and modulate COX-2 mRNA level.
목차
등록된 정보가 없습니다.
참고문헌 (12)
참고문헌 신청
/ 1996 / Lipid peroxidation and antioxidase activities on hairless mouse induced by UVB irradiation and effects of tannic acid Korean Journal of Environmental Health 22 (4) :
/ 1999 / Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components International Journal of Immunopharmacology 21 : 303
/ 2000 / Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation 62 : 367 ~ 384
/ 2001 / Inhibitory effect of Astragali Radix on COX-2 activity The Korean Society of Pharmacognosy 32 (4) : 311 ~ 315
/ 2001 / SAR of COX-2 inhibitors 9 : 69 ~ 78
/ 1999 / Prevention of ultraviolet radiation-induced suppression of contact hypersensitivity by Aloe vera gel components International Journal of Immunopharmacology 21 : 303
/ 2000 / Topical application of a selective cyclooxygenase inhibitor suppresses UVB mediated cutaneous inflammation 62 : 367 ~ 384
/ 2001 / Inhibitory effect of Astragali Radix on COX-2 activity The Korean Society of Pharmacognosy 32 (4) : 311 ~ 315
/ 2001 / SAR of COX-2 inhibitors 9 : 69 ~ 78
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