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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제40권 제4호
- 발행연도
- 2006.1
- 수록면
- 255 - 262 (8page)
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초록· 키워드
오류제보하기
Background : Secondary spinal cord injury (SCI) that follows an initial mechanical insult can
exacerbate the overall damage, limit the restorative processes and eventually lead to an increased
neurological deficit. We hypothesized that selective inhibition of cyclooxygenase-2
(COX-2) may decrease the delayed cell death, and so this will contribute to decreased level
of the secondary injury. Methods : The dorsal surface of the cord at the T9 level was subjected
to weight drop impact using a 10 g rod. To block COX-2 activation, a selective COX-2 inhibitor
(NS-398) was administered (5 mg/kg, i.p.) 15 min prior to SCI. The COX-1, COX-2, Caspase-3
and PGE2 expressions were measured by real time quantitative RT-PCR and fluorescence
immunostaining. Results : Many activated caspase-3 positive cells were observed at 6 h and
they increased until 72 h after SCI. The expression of COX-2 peaked at 6 h after SCI, while
the COX-1 expression was unaffected. The principal cells that showed a COX-2 expression
were the neurons and microglia. Pretreatment with NS-398 caused a significant decrease in
the expression of prostaglandin E2 and activated caspase-3 positive cells after SCI. Conclusion
: These data suggest that COX-2 is one of the main factors related with the pathologic
deficits from secondary SCI.
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참고문헌 (28)
참고문헌 신청
/ / Pathology of experimental spinal cord trauma The necrotic lesion as a function of vascular injury : 236 ~ 53
/ 1976 / Prediction of mobility gains in patients withcervical spinal cord injuries 45 : 677 ~ 82
/ 1993 / Secondary injury mechanisms in acute spinal cord injury 11 (1) : 13 ~ 22
/ 1996 / COX-2,a synaptically induced enzyme,is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex 93 : 2317 ~ 2321
/ 1996 / Cyclooxygenase-2 induction in cerebral cortex:an intracellular response to synaptic excitation 66 : 6 ~ 13
/ 1976 / Prediction of mobility gains in patients withcervical spinal cord injuries 45 : 677 ~ 82
/ 1993 / Secondary injury mechanisms in acute spinal cord injury 11 (1) : 13 ~ 22
/ 1996 / COX-2,a synaptically induced enzyme,is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex 93 : 2317 ~ 2321
/ 1996 / Cyclooxygenase-2 induction in cerebral cortex:an intracellular response to synaptic excitation 66 : 6 ~ 13
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