지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.12
- 수록면
- 371 - 377 (7page)
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Purpose: Cox-2 expression in breast carcinoma has been reported to be related to angiogenesis, lymph node metastasis and Her-2 expression. The aim of this study is to evaluate the clinicopathologic significance of Cox-2 expression in the invasive ductal carcinomas (IDC) and intraductal carcinomas (DCIS) of the breast.
Methods: The materials were 353 IDC cases and 82 DCIS cases. Immunohistochemical stain for Cox-2 was interpreted as 1＋ (weak & focal) and 2＋ (diffuse), and the relationships between Cox-2 and ER, PR, Her-2, p53, Ki-67 and bcl-2 expressions were analyzed.
Results: There was no significant difference of Cox-2 expression between IDC (148/353, 41.9%) and DCIS (38/82, 46.3%). Cox-2 (2＋) expression was more frequent in low grade than intermediate and high grade IDC, but the difference was not significant statistically (P=0.0833), and there were no significant differences of Cox-2 expression according to age, tumor size, nuclear grade, lymph node metastasis in IDC and DCIS cases. In IDC cases, Cox-2 (1＋ and 2＋) expression showed positive relationships with p53 (＋) and more than 10% of Ki-67 labeling index (P=0.0029, P=0.0015), and revealed tendencies of positive relationships with ER (＋) and bcl-2 (＋) (P=0.0750, P=0.0776). However, no significant relationship between Cox-2 and Her-2 expressions was recognized. In DCIS cases, Cox-2 (2＋) expression rate was increased in cases showing negative for Her-2 (P=0.0092) and positive for bcl-2 (P=0.0486).
Conclusion: Cox-2 expression seems to be involved in the development of breast carcinomas, but not related to the invasiveness. Cox-2 expression, especially 2＋, in the DCIS cases suggest a possibility of less aggressive biological behavior.
Methods: The materials were 353 IDC cases and 82 DCIS cases. Immunohistochemical stain for Cox-2 was interpreted as 1＋ (weak & focal) and 2＋ (diffuse), and the relationships between Cox-2 and ER, PR, Her-2, p53, Ki-67 and bcl-2 expressions were analyzed.
Results: There was no significant difference of Cox-2 expression between IDC (148/353, 41.9%) and DCIS (38/82, 46.3%). Cox-2 (2＋) expression was more frequent in low grade than intermediate and high grade IDC, but the difference was not significant statistically (P=0.0833), and there were no significant differences of Cox-2 expression according to age, tumor size, nuclear grade, lymph node metastasis in IDC and DCIS cases. In IDC cases, Cox-2 (1＋ and 2＋) expression showed positive relationships with p53 (＋) and more than 10% of Ki-67 labeling index (P=0.0029, P=0.0015), and revealed tendencies of positive relationships with ER (＋) and bcl-2 (＋) (P=0.0750, P=0.0776). However, no significant relationship between Cox-2 and Her-2 expressions was recognized. In DCIS cases, Cox-2 (2＋) expression rate was increased in cases showing negative for Her-2 (P=0.0092) and positive for bcl-2 (P=0.0486).
Conclusion: Cox-2 expression seems to be involved in the development of breast carcinomas, but not related to the invasiveness. Cox-2 expression, especially 2＋, in the DCIS cases suggest a possibility of less aggressive biological behavior.
목차
서론
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고찰
결론
REFERENCES
참고문헌 (19)
참고문헌 신청
1. [학술지(정기간행물)] - Kelly LM / 2003 / Lack of prognostic effect of Cox-2 expression in primary breast cancer on short-term follow-up / Eur J Surg Oncol 29 : 707 ~ 710
2. [학술지(정기간행물)] - Costa C / 2002 / Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer / J Clin Pathol 55 : 429 ~ 434
3. [학술지(정기간행물)] - Park K / 2006 / Cox-2 expression on tissue microarray of breast cancer / Eur J Surg Oncol 32 : 1093 ~ 1096
4. [학술지(정기간행물)] - Wulfing P / 2003 / Analysis of cyclooxygenase-2 expression in human breast cancer: high throughput tissue microarray analysis / J Cancer Res Clin Oncol 129 : 375 ~ 382
5. [학술지(정기간행물)] - Khuder SA / 2001 / Breast cancer and NSAID use: a meta-analysis / Br J Cancer 84 : 1188 ~ 1192
2. [학술지(정기간행물)] - Costa C / 2002 / Cyclo-oxygenase 2 expression is associated with angiogenesis and lymph node metastasis in human breast cancer / J Clin Pathol 55 : 429 ~ 434
3. [학술지(정기간행물)] - Park K / 2006 / Cox-2 expression on tissue microarray of breast cancer / Eur J Surg Oncol 32 : 1093 ~ 1096
4. [학술지(정기간행물)] - Wulfing P / 2003 / Analysis of cyclooxygenase-2 expression in human breast cancer: high throughput tissue microarray analysis / J Cancer Res Clin Oncol 129 : 375 ~ 382
5. [학술지(정기간행물)] - Khuder SA / 2001 / Breast cancer and NSAID use: a meta-analysis / Br J Cancer 84 : 1188 ~ 1192
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Clinical Value of Cyclooxygenase-2 Expression in Human Breast Carcinoma
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Effects of natural extracts on COX-1 and COX-2 mRNA expression on UVB-induced skin inflammation in C57BL/6 mouse
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2006 .01
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자궁경부 편평세포암에서 COX-1, COX-2, p53, VEGF의 발현과 예후인자와의 관련성
Obstetrics & Gynecology Science
2005 .01
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Expression of Cyclooxygenase-2 Protein in Gastric Carcinogenesis
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Correlation between COX-2 Expression and Hormone Receptors in Invasive Ductal Breast Cancer
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2010 .03
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Synthesis and Biological Activity of Annulated Pyrazoles as Selective COX-2 Inhibitors. I.
Archives of pharmacal research : a publication of the Pharmaceutical Society of Korea
1999 .01
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Cyclooxygenase-2 and p53 Expression as Prognostic Indicators in Conventional Renal Cell Carcinoma
Yonsei Medical Journal
2005 .01
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원발성 비소세포폐암조직에서 Cyclooxygenase-2 발현의 예후인자로서의 의의
Tuberculosis and Respiratory Diseases
2004 .01
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UCI(KEPA) : I410-ECN-0101-2013-514-002680379