지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 206 - 214 (9page)
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초록· 키워드
오류제보하기
Background: Immune responses appear to be affected by anesthetics and analgesics. We investigated the effects of caudal tramadol on the postoperative immune response and pain management in pediatric patients.Methods: Sixty ASA-I pediatric patients aged 3-10 years undergoing lower abdominal surgery. Patients were randomly assigned either to a caudal bupivacaine (0.25%) group (group B), or a group that received caudal tramadol (1 mg/kg) added to the bupivacaine (0.25%) (group T). Both were diluted in a 0.9% NaCl solution to a total volume of 1ml/ kg. The systemic immune response was measured by collecting blood samples preoperatively, at the end of anesthesia, and at 24 and 72 hours postoperatively, and studied for interleukin IL-6, C-reactive proteins (CRP) cortisol levels, and leucocytes with its differential count. Postoperative pain was assessed along with sedation scales.Results: Postoperative production of IL-6 was significantly higher in group B at the end of anesthesia, than at the 24th hour, and at the 72nd hour in group B and group T, respectively. The immune response showed leukocytosis with increased percentages of neutrophil and monocytes, and a decreased lymphocyte response rate within both groups with no significant differences between the groups. Cortisol and CRP were significantly higher in group B.Conclusions: Adding tramadol to a caudal bupivacaine block can attenuate the pro-inflammatory cytokine response, Cortisol, and CRP in children undergoing lower abdominal surgery. (Korean J Pain 2018; 31: 206-14)
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등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Khan S / 2008 / Comparison of caudal bupivacaine and bupivacaine-tramadol for postoperative analgesia in children with hypospadias repair / J Coll Physicians Surg Pak 18:601~604
Stefano GB / 1996 / Opioid and opiate immunoregulatory processes / Crit Rev Immunol 16:109~144
Webster NR / 1998 / Opioids and the immune system / Br J Anaesth 81:835~836
Carli F / 2002 / Epidural analgesia enhances functional exercise capacity and health-related quality of life after colonic surgery: results of a randomized trial / Anesthesiology 97:540~549
Hole A / 1982 / Monocyte functions are depressed during and after surgery under general anaesthesia but not under epidural anaesthesia / Acta Anaesthesiol Scand 26:301~307
Stefano GB / 1996 / Opioid and opiate immunoregulatory processes / Crit Rev Immunol 16:109~144
Webster NR / 1998 / Opioids and the immune system / Br J Anaesth 81:835~836
Carli F / 2002 / Epidural analgesia enhances functional exercise capacity and health-related quality of life after colonic surgery: results of a randomized trial / Anesthesiology 97:540~549
Hole A / 1982 / Monocyte functions are depressed during and after surgery under general anaesthesia but not under epidural anaesthesia / Acta Anaesthesiol Scand 26:301~307
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