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논문 기본 정보

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학술저널
저자정보
Gopireddy Rajesh (Post Graduate Institute of Medical Education and Research Chandigarh India) Rangasamy Karthick (Post Graduate Institute of Medical Education and Research Chandigarh India) Goni Vijay G. (Post Graduate Institute of Medical Education and Research Chandigarh India) Vatsya Pulak (All India Institute of Medical Sciences (New Delhi) New Delhi India) Behera Prateek (All India Institute of Medical Sciences (Bhopal) Bhopal India) Batra Yatindra K. (Post Graduate Institute of Medical Education and Research) Vaishnavi Chetana (Post Graduate Institute of Medical Education and Research)
저널정보
대한척추외과학회 Asian Spine Journal Asian Spine Journal Vol.15 No.6
발행연도
2021.12
수록면
753 - 760 (8page)
DOI
10.31616/asj.2020.0295

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Study Design: Prospective cohort study. Purpose: Inflammatory cytokines produced at the site of disc herniation are considered as pain generators in patients with lumbar disc disease. Whether a high-sensitivity C-reactive protein (hs-CRP) assay can be used in order to predict the quantum of inflamma tion surrounding nerve roots is a matter of investigation. This study aimed to evaluate the association of hs-CRP level and functional outcomes measured by the Modified Oswestry Low Back Pain Disability Questionnaire (MODY) before and after epidural steroid injec tion (ESI) in patients with lumbar disc disease. Overview of Literature: Although many studies examining the role of hs-CRP levels and lumbar pain have been published previ ously, the results are equivocal, and there is no clear consensus regarding which patients will benefit from an ESI. Methods: This was a prospective study, with 77 patients in the study group and 23 participants in the control group. Baseline hs CRP levels were obtained for both groups. Study group patients received a single ESI and were subjected to detailed pre- and post procedure evaluation using MODY scores. For this group, hs-CRP levels were measured at 1 and 2 months after injection. Results: Out of 77 patients, 52 had acute and 25 had chronic low back pain. Thirty-six patients with acute pain obtained significant improvement, while 16 had an insignificant response to the ESI. None of the chronic cases had a significant response. The mean baseline hs-CRP (mg/L) among the study group (29.83±10.43) was significantly higher than for the controls (10.26±2.783). The base line hs-CRP among acute cases, where post ESI MODY score at 2 months had significant reduction, was 32.19±5.126, and those with insignificant reduction was 18.13±7.949 (p<0.001). Conclusions: Baseline hs-CRP levels can be used to prognosticate the outcome following ESI in patients with acute lumbar disc dis ease, with radicular pain refractory to physiotherapy and analgesics.
#Lumbar #Disc prolapse #C-reactive protein #Epidural steroid injection #Low backache #Interlaminar #Inflammatory marker

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참고문헌 (31)

참고문헌 신청
GBD 2017 Disease / 2018 / Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017 : a systematic analysis for the Global Burden of Disease Study 2017 / Lancet 392:1789~1858 google schola Sudhir Ganesan / 2017 / Prevalence and Risk Factors for Low Back Pain in 1,355 Young Adults: A Cross-Sectional Study / Asian Spine Journal 11(4):610~617 dbpia Zhang Y / 2008 / Advances in susceptibility genetics of intervertebral degenerative disc disease / Int J Biol Sci 4:283~290 google schola Kang JD / 1996 / Herniated lumbar intervertebral discs spontaneously produce matrix metalloproteinases, nitric oxide, interleukin-6, and prostaglandin E2 / Spine(Phila Pa 1976) 21:271~277 google schola Mulleman D / 2006 / Pathophysiology of disk-related sciatica:I. evidence supporting a chemical component / Joint Bone Spine 73:151~158 google schola

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