지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 595 - 603 (9page)
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초록· 키워드
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Background/Aims: C-reactive protein (CRP) is an easily measured index of disease activity, but its ability to predict clinical course is controversial. We therefore designed a study to determine whether the CRP level at Crohn’s disease (CD) diagnosis is a valuable indicator of the disease phenotype, activity, and clinical course. Methods: We retrospectively analyzed 705 CD patients from 32 institutions. The patients were classified into two groups according to CRP level. The patients’ demographic and clinical characteristics and their use of immunosuppressive or biological agents were recorded. Disease location and behavior, hospitalization, and surgery were analyzed. Results: A high CRP was associated with younger age, steroid use, colonic or ileocolonic location, high CD activity index, and active inflammation at colonoscopy (p<0.001). As the disease progressed, patients with high CRP were more likely to exhibit strictures (p=0.027).
There were significant differences in the use of 5-aminosalicylic acid, antibiotics, corticosteroids, azathioprine, and infliximab (p<0.001, p<0.001, p<0.001, p<0.001, and p=0.023, respectively). Hospitalization was also more frequent in patients with high CRP. Conclusions: The CRP level at diagnosis is useful for evaluating the phenotype, activity, and clinical course of CD. Closer follow-up strategies, with early aggressive treatment, could be considered for patients with high CRP.
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참고문헌 (33)
참고문헌 신청
Mazor Y / 2011 / Prediction of disease complication occurrence in Crohn’s disease using phenotype and genotype parameters at diagnosis / J Crohns Colitis 5:592~597
정윤숙 / 2013 / Seasonal Variation in Months of Birth and Symptom Flares in Korean Patients with Inflammatory Bowel Disease / Gut and Liver 7(6):661~667
Chen-Wang Chang / 2015 / Intestinal Stricture in Crohn’s Disease / Intestinal research 13(1):19~26
Pin-Jin Hu / 2015 / Inflammatory Bowel Disease in Asia: The Challenges and Opportunities / Intestinal research 13(3):188~190
Paulo Gustavo Kotze / 2015 / Conventional Versus Biological Therapy for Prevention of Postoperative Endoscopic Recurrence in Patients With Crohn’s Disease: an International, Multicenter, and Observational Study / Intestinal research 13(3):259~265
정윤숙 / 2013 / Seasonal Variation in Months of Birth and Symptom Flares in Korean Patients with Inflammatory Bowel Disease / Gut and Liver 7(6):661~667
Chen-Wang Chang / 2015 / Intestinal Stricture in Crohn’s Disease / Intestinal research 13(1):19~26
Pin-Jin Hu / 2015 / Inflammatory Bowel Disease in Asia: The Challenges and Opportunities / Intestinal research 13(3):188~190
Paulo Gustavo Kotze / 2015 / Conventional Versus Biological Therapy for Prevention of Postoperative Endoscopic Recurrence in Patients With Crohn’s Disease: an International, Multicenter, and Observational Study / Intestinal research 13(3):259~265
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