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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 199 - 204 (6page)
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Purpose: The purpose of this study is to investigate the epithelial-mesenchymal transition (EMT) induced by Snail transcription factor and Snailtransfectedin vivo tumors with histopathological features.
Materials and methods: We induced in vivo xenografted tumorigenesis in the oral vestibules of nude mice by a Snail transfected HaCaT cell lineand investigated morphological and immunohistochemical features in Snail expressive tumors.
Results: We identified tumor masses in 14 out of 15 nude mice in the HaCaT-Snail cell inoculation group, but no tumors were present in any of theHaCaT cell inoculation group. Induced tumors showed features of poorly differentiated carcinoma with invasion to neighboring muscles and bones.
The HaCaT-Snail tumors showed decreased expressions of E-cadherin and cytokeratin, but showed increased expressions of vimentin and N-cadherin.
Discussion: The Snail transfected xenograft can improve productivity of malignant tumors, show various histopathological features including invasivegrowth, and aid in the investigation of tumor progression and the interaction with surrounding tissues.
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참고문헌 (26)
참고문헌 신청
[학
Arias AM / 2001 / Epithelial mesenchymal interactions in cancer and development / Cell 105 : 424 ~ 431
Bouley JL / 1987 / The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers / Nature 330 (6146) : 395 ~ 398
Brabletz T / 2005 / Invasion and metastasis in colorectal cancer: Epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin / Cells Tis
Bracke ME / 1996 / The E-cadherin/catenin complex in invasion metastasis, in In Attempts to Understand Metastasis Formation I / Springer : 123 ~ 161
Arias AM / 2001 / Epithelial mesenchymal interactions in cancer and development / Cell 105 : 424 ~ 431
Bouley JL / 1987 / The Drosophila developmental gene snail encodes a protein with nucleic acid binding fingers / Nature 330 (6146) : 395 ~ 398
Brabletz T / 2005 / Invasion and metastasis in colorectal cancer: Epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin / Cells Tis
Bracke ME / 1996 / The E-cadherin/catenin complex in invasion metastasis, in In Attempts to Understand Metastasis Formation I / Springer : 123 ~ 161
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