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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 74 - 82 (9page)
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초록· 키워드
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In order to make successful oral cancer treatment, we need to understand about tumor biology and effective chemotherapeutic agents. To achieve
these studies, it is necessary to develope a proper in-vivo model. Therefore the author will make try to develop more improved animal model of more
applicable in various method of cancer study.
In this study, the author induced in-vivo tumorigenesis in nude mice by YD-10Bmod cell line used by YD-10B cell line originated from oral tongue
squamous cell carcinoma and observed tumor formations and invasiveness of surrounding tissue, and found some results as follows :
1. The experimental group (YD-10Bmod, subcutaneous injection) produced tumors 13 out of 15 mice, while the control group produced none of 5
mice.
2. The inoculation of 1×106cells/mouse produced tumors 3 out of 5 mice and inoculation of 1×107cells/mouse, 2×107cells/mouse produced
tumors in every 5 mice.
3. In the histopathologic studies, the inoculation of 1×106cells/mouse group showed the characteristic features of well-differentiated squamous cell
carcinoma and demarcated expansile growth, while the inoculation of 1×107cells/mouse, 2×107cells/mouse group showed the expansile growth
with partial central necrosis and invasive growth to surrounding fat & connective tissue.
These findings suggest that atopic xenograft of YD-10Bmod cell line in nude mice has a improved productivity of tumors, produced tumors showed
the characteristics feature of human tumor and invasive growth to surrounding tissue in histopathologic appearance. These atopic nude mouse model
of tongue carcinoma might assist in studying oral cancer biology and effective choice of chemotherapeutic agents.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Carew JF / 2003 / Factors affecting choice of treatment. In Oral Cancer / Martin Dunitz : 209 ~ 213
Fidler IJ / 1986 / Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis / Cancer Metastasis Rev 5 : 29 ~ 49
Fu XY / 1991 / Extensive multi organ metastasis following orthotopic onplantation of histologically intact human bladder carcinoma tissue in nude mice / Int J Cancer 49 : 93
Giovanella BC / 1973 / Heterotransplantation of human malignant tumors in nude thymusless mice 1. Breathing and maintenance of nude mice / J Natl Cancer Inst 51 : 615 ~ 619
Giovanella BC / 1974 / Heterotransplantation of human malignant tumors in nude thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human
Fidler IJ / 1986 / Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis / Cancer Metastasis Rev 5 : 29 ~ 49
Fu XY / 1991 / Extensive multi organ metastasis following orthotopic onplantation of histologically intact human bladder carcinoma tissue in nude mice / Int J Cancer 49 : 93
Giovanella BC / 1973 / Heterotransplantation of human malignant tumors in nude thymusless mice 1. Breathing and maintenance of nude mice / J Natl Cancer Inst 51 : 615 ~ 619
Giovanella BC / 1974 / Heterotransplantation of human malignant tumors in nude thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human
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