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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2011.1
- 수록면
- 12 - 18 (7page)
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Background/Aims: E-cadherin is involved in intercellular binding and cellular polarity formation. Snail is a key regulator of the epithelial-mesenchymal transition and is closely associated with tumor invasiveness due to its ability to suppress E-cadherin expression. We investigated the expressions of E-cadherin and Snail in hepatocellular carcinoma (HCC) tissue to determine the clinical significance of these proteins in HCC. Methods: Immunohistochemistry was used to examine the expressions of E-cadherin and Snail in resected tissues from 59 patients diagnosed with HCC. We also evaluated the relationship between the expressions of these two molecules in HCC tissue and clinicopathologic factors in the patients. Results: Immunohistochemistry showed that Snail was stained in 20.3% of the HCC tissues and 3.4% of noncancerous tissues. Snail was not stained in the area of E-cadherin expression. The expression of Snail in the HCC tissue was associated with poorly differentiated HCC (P=0.028). The expression of Snail without E-cadherin staining in HCC tissue was significantly associated with postoperative HCC recurrence (P=0.013). Conclusions: The expression of Snail in HCC tissue was associated with decreased expression of E-cadherin and poorly differentiated HCC. The expression of Snail without E-cadherin staining in HCC was associated with postoperative recurrence.
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참고문헌 (30)
참고문헌 신청
Bae SH / 2002 / Expression patterns of E-cadherin and beta-catenin according to clinicopathological characteristics of hepatocellular carcinoma / Taehan Kan Hakhoe Chi 8:297~303
Batlle E / 2000 / The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells / Nat Cell Biol 2:84~89
Yokoyama K / 2001 / Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro / Oral Oncol 37:65~71
Ihara A / 1996 / Expression of epithelial cadherin and alpha- and beta-catenins in nontumoral livers and hepatocellular carcinomas / Hepatology 23:1441~1447
Wei Y / 2002 / Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features / Hepatology 36:692~701
Batlle E / 2000 / The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells / Nat Cell Biol 2:84~89
Yokoyama K / 2001 / Reverse correlation of E-cadherin and snail expression in oral squamous cell carcinoma cells in vitro / Oral Oncol 37:65~71
Ihara A / 1996 / Expression of epithelial cadherin and alpha- and beta-catenins in nontumoral livers and hepatocellular carcinomas / Hepatology 23:1441~1447
Wei Y / 2002 / Altered expression of E-cadherin in hepatocellular carcinoma: correlations with genetic alterations, beta-catenin expression, and clinical features / Hepatology 36:692~701
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