지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2014.3
- 수록면
- 1 - 5 (5page)
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Xenograft models of human cancer play an important role in the screening and evaluation of candidates for new anticancer agents. The models, which are derived from human tumor cell lines and are classified according to the transplant site, such as ectopic xenograft and orthotopic xenograft, are still utilized to evaluate therapeutic efficacy and toxicity. The metastasis model is modified for the evaluation and prediction of cancer progression. Recently, animal models are made from patient-derived tumor tissue. The patient-derived tumor xenograft models with physiological characters similar to those of patients have been established for personalized medicine. In the discovery of anticancer drugs, standard animal models save time and money and provide evidence to support clinical trials. The current strategy for using xenograft models as an informative tool is introduced.
목차
INTRODUCTION
CONCLUSION
REPERENCES
참고문헌 (33)
참고문헌 신청
Teicher, B.A / 2004 / Anticancer drug development guide; preclinical screening, clinical trials, and approval / Humana Press :99~123
Cheon, D.J / 2011 / Mouse models of cancer / Annu. Rev. Phytopathol 6:95~119
Suggitt, M / 2005 / 50 years of preclinical anticancer drug screening: empirical to target-driven approaches / Clin. Cancer Res 11:971~981
Frese, K.K / 2007 / Maximizing mouse cancer models / Nat. Rev. Cancer 7:645~658
Sharpless, N.E / 2006 / The mighty mouse: genetically engineered mouse models in cancer drug development / Nat. Rev. Drug Discovery 5:741~754
Cheon, D.J / 2011 / Mouse models of cancer / Annu. Rev. Phytopathol 6:95~119
Suggitt, M / 2005 / 50 years of preclinical anticancer drug screening: empirical to target-driven approaches / Clin. Cancer Res 11:971~981
Frese, K.K / 2007 / Maximizing mouse cancer models / Nat. Rev. Cancer 7:645~658
Sharpless, N.E / 2006 / The mighty mouse: genetically engineered mouse models in cancer drug development / Nat. Rev. Drug Discovery 5:741~754
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UCI(KEPA) : I410-ECN-0101-2015-510-001343973