지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 294 - 298 (5page)
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초록· 키워드
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Purpose: The development of a microvascularization is important for the homeostasis of normal bone. Vascular endothelial growth factor (VEGF)
is one of the most important factors in vessel formation. The purpose of this study was to examine VEGF-related autocrine growth in periostealderived
cells.
Materials and methods: Periosteal-derived cells were obtained from mandibular periosteums and introduced into the cell culture. After passage 3,
the periosteal-derived cells were further cultured for 21 days in an osteogenic inductive culture medium containing dexamethasone, ascorbic acid, and
β-glycerophosphate.
Results: The expression of four VEGF isoforms and VEGFRs was observed in periosteal-derived cells. Treatment with cultures with VEGFR-1 and
VEGFR-2 Kinase Inhibitor inhibited osteoblastic differentiation and alkaline phosphatase (ALP) activity of periosteal-derived cells. In addition,
exogenous VEGF treatment increased calcium content in the periosteal-derived cells.
Conclusion: These results suggest that VEGF might act as an autocrine growth molecule during osteoblastic differentiation of cultured human
periosteal-derived cells.
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참고문헌 (18)
참고문헌 신청
Furumatsu T / 2003 / Vascular endothelial growh factor prinicipally acts as the main angiogenic factor in the early stage of human osteoblastogenesis / J Biochem 133 : 633 ~
Gee MF / 2005 / Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid / Oncogene 24
Gerber HP / 1999 / VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation / Nat Med 5 : 623 ~ 628
Haper J / 2001 / Neuropilin-1 expression in osteogenic cells: down-regulation during differentiation of osteoblasts into osteocytes / J Cell Biochem 81 : 82 ~ 92
Maes C / 2002 / Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 / Mech Dev 111 : 61
Gee MF / 2005 / Vascular endothelial growth factor acts in an autocrine manner in rhabdomyosarcoma cell lines and can be inhibited with all-trans-retinoic acid / Oncogene 24
Gerber HP / 1999 / VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation / Nat Med 5 : 623 ~ 628
Haper J / 2001 / Neuropilin-1 expression in osteogenic cells: down-regulation during differentiation of osteoblasts into osteocytes / J Cell Biochem 81 : 82 ~ 92
Maes C / 2002 / Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188 / Mech Dev 111 : 61
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