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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 218 - 223 (6page)
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초록· 키워드
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Purpose
Although the vascular endothelial growth factor (VEGF) superfamily has been identified to critically influence tumor-related angiogenesis, the prognostic significance of a VEGF expression in gastric cancer is still controversial. Accordingly, the present study analyzed the VEGF-A and VEGF-C expressions and their impact on the prognosis of patients with gastric cancer.
Materials and Methods
Three hundred seventy-five consecutive patients who underwent surgical resection for gastric adenocarcinoma with a curative intent were enrolled in the present study. Immunohistochemical staining for VEGF-A and VEGF-C was performed using the formalin fixed, paraffin embedded tumor tissues.
Results
Positive VEGF-A and VEGF-C expressions were observed in 337 (90.1%) and 278 (74.9%) cases, respectively. The survival analysis showed that the expression of VEGF-A and VEGF-C had no effect on the OS and DFS. On the multivariate analysis that included age, gender and the TNM stage, no significant association between the grade of the VEGF-A or VEGF-C expression and survival was observed.
Conclusion
The current study suggests that the tissue expression of VEGF-A or VEGF-C alone is not an independent prognostic marker for patients with surgically resected gastric adenocarcinoma.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Amioka T / 2002 / Vascular endothelial growth factor-C expression predicts lymph node metastasis of human gastric carcinomas invading the submucosa / Eur J Cancer 38 : 1413
Anderson C / 2006 / Molecular markers for gastric adenocarcinoma: an update / Mol Diagn Ther 10 : 345 ~ 352
Cao Y / 1998 / Vascular endothelial growth factor C induces angiogenesis in vivo / Proc Natl Acad Sci U S A 95 : 14389 ~ 14394
Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407 : 249 ~ 257
Fontanini G / 2002 / A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung ca
Anderson C / 2006 / Molecular markers for gastric adenocarcinoma: an update / Mol Diagn Ther 10 : 345 ~ 352
Cao Y / 1998 / Vascular endothelial growth factor C induces angiogenesis in vivo / Proc Natl Acad Sci U S A 95 : 14389 ~ 14394
Carmeliet P / 2000 / Angiogenesis in cancer and other diseases / Nature 407 : 249 ~ 257
Fontanini G / 2002 / A high vascular count and overexpression of vascular endothelial growth factor are associated with unfavourable prognosis in operated small cell lung ca
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