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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제39권 제2호
- 발행연도
- 2005.1
- 수록면
- 99 - 105 (7page)
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Background : Vascular endothelial growth factor (VEGF)-C and VEGF-D are novel growth factors that regulate lymphatic vessel growth. This study was designed to examine whether the expression of three VEGF family members, VEGF-A, VEGF-C and VEGF-D are associated with the clinicopathologic parameters, especially with lymph node metastasis, in advanced gastric carcinomas. Methods : Immunohistochemical staining was performed for VEGF-A, VEGF-C, and VEGF-D in the surgically resected specimens from 102 patients with advanced gastric carcinoma. The mRNA expressions of the three VEGF family members were assessed in 16 cases of tumor tissues and their corresponding non-neoplastic tissues. Results : Of the 102 gastric carcinomas, 74 (73%), 82 (80%), and 34 (33%) cases showed cytoplasmic immuno-reactivity for VEGF-A, VEGF-C and VEGF-D, respectively. Both VEGF-A and VEGF-C expressions were associated with lymphatic invasion and lymph node metastasis (p<0.05), but the VEGF-D expression was not associated with them (p>0.05). In the tumor tissue, VEGF-C mRNA expression was greater, while VEGF-D mRNA expression was lower than in the non-neoplatic tissue adjacent to the tumor. Conclusions : VEGF-A and VEGF-C may play important roles for the lymphatic spread of gastric carcinoma. We suggest that neutralizing both VEGF-A and VEGF-C may be reguired to block lymph node metastasis.
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참고문헌 (25)
참고문헌 신청
/ / is a ligand for the tyrosine kinases VEGF receptor2 : 548 ~ 53
/ 1983 / Tumor cells secrete a vascular permeability factor that promotesaccumulation of ascites fluid 219 : 983 ~ 5
/ 1987 / Transport of molecules in the tumor interstitium:a review 47 : 3039 ~ 51
/ 1995 / Expression of the fmsliketyrosine kinase 4 gene becomes restricted to lymphatic endotheliumduring development 92 : 3566 ~ 70
/ 1996 / Identification ofa c-fos-induced gene that is related to the platelet-derived growthfactor/vascular endothelial growth factor family 93 : 11675 ~ 80
/ 1983 / Tumor cells secrete a vascular permeability factor that promotesaccumulation of ascites fluid 219 : 983 ~ 5
/ 1987 / Transport of molecules in the tumor interstitium:a review 47 : 3039 ~ 51
/ 1995 / Expression of the fmsliketyrosine kinase 4 gene becomes restricted to lymphatic endotheliumduring development 92 : 3566 ~ 70
/ 1996 / Identification ofa c-fos-induced gene that is related to the platelet-derived growthfactor/vascular endothelial growth factor family 93 : 11675 ~ 80
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