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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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- 2014.1
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Vascular endothelial growth factor (VEGF)-VEGF receptor (VEGFR) system has been shown to play central roles not only in physiological angiogenesis, but also in pathological angiogenesis in diseases such as cancer. Based on these findings, a variety of anti-angiogenic drugs, including anti-VEGF antibodies and VEGFR/multi-receptor kinase inhibitors have been developed and approved for the clinical use. While the clinical efficacy of these drugs has been clearly demonstrated in cancer patients, they have not been shown to be effective in curing cancer, suggesting that further improvement in their design is necessary. Abnormal expression of an endogenous VEGF-inhibitor sFlt-1 has been shown to be involved in a variety of diseases, such as preeclampsia and aged macular degeneration. In addition, various factors modulating angiogenic processes have been recently isolated. Given this complexity then, extensive studies on the interrelationship between VEGF signals and other angiogenesis-regulatory systems will be important for developing future strategies to suppress diseases with an angiogenic component.
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참고문헌 (81)
참고문헌 신청
Alitalo, K / 2002 / Molecular mechanisms of lymphangiogenesisin health and disease / Cancer Cell 1:219~227
Ambati, B. K / 2006 / Corneal avascularityis due to soluble VEGF receptor-1 / Nature 443:993~997
Barleon, B / 1996 / Migration of human monocytes in response tovascular endothelilal growth factor(VEGF)is mediated via theVEGF receptor flt-1 / Blood 87:3336~3343
Beck, H / 2010 / VEGFR-1 signalingregulates the homing of bone marrow derived cells in a mousestroke model / J. Neuropathol. Exp. Neurol 69:168~175
Bellomo, D / 2000 / Mice lacking the vascularendothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctionalcoronary vasculature, and impaired recovery from cardiacischemia / Circ. Res 86:E29~E35
Ambati, B. K / 2006 / Corneal avascularityis due to soluble VEGF receptor-1 / Nature 443:993~997
Barleon, B / 1996 / Migration of human monocytes in response tovascular endothelilal growth factor(VEGF)is mediated via theVEGF receptor flt-1 / Blood 87:3336~3343
Beck, H / 2010 / VEGFR-1 signalingregulates the homing of bone marrow derived cells in a mousestroke model / J. Neuropathol. Exp. Neurol 69:168~175
Bellomo, D / 2000 / Mice lacking the vascularendothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctionalcoronary vasculature, and impaired recovery from cardiacischemia / Circ. Res 86:E29~E35
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