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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 341 - 345 (5page)
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Introduction: Skeletal homeostasis is normally maintained by the stability between bone formation by osteoblasts and bone resorption by osteoclasts.
However, the correlation between the inflammatory reaction and osteoblastic differentiation of cultured osteoprogenitor cells has not been fully investigated. This study examined the effects of inflammatory cytokines on the osteoblastic differentiation of cultured human periosteal-derived cells.
Materials and Methods: Periosteal-derived cells were obtained from the mandibular periosteum and introduced into the cell culture. After passage 3, the periosteal-derived cells were further cultured in an osteogenic induction Dulbecco’s modified Eagle’s medium (DMEM) medium containing dexamethasone, ascorbic acid, and β-glycerophosphate. In this culture medium, tumor necrosis factor (TNF)-αwith different concentrations (0.1, 1,and 10 ng/mL) or interleukin (IL)-1βwith different concentrations (0.01, 0.1, and 1 ng/mL) were added.
Results: Both TNF-αand IL-1βstimulated alkaline phosphatase (ALP) expression in the periosteal-derived cells. TNF-αand IL-1βincreased the level of ALP expression in a dose-dependent manner. Both TNF-αand IL-1βalso increased the level of alizarin red S staining in a dose-dependent manner during osteoblastic differentiation of cultured human periosteal-derived cells.
Conclusion: These results suggest that inflammatory cytokines TNF-αand IL-1βcan stimulate the osteoblastic activity of cultured human periosteal-derived cells.
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참고문헌 (21)
참고문헌 신청
Ammann P / 1997 / Transgenic mice expressing soluble tumor necrosis factor-receptor are protected against bone loss caused by estrogen deficiency / J Clin Invest 99 : 1699 ~
Benatti BB / 2009 / Inflammatory and bone-related genes are modulated by aging in human periodontal ligament cells / Cytokine 46 : 176 ~ 181
Doherty TM / 2003 / Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads / Proc Natl Acad Sci U S A 100 : 11201 ~ 11206
Gilbert L / 2002 / Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor- alpha / J Biol Chem 277 : 2695 ~
Ji H / 2002 / Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis / J Exp Med 196 : 77 ~ 85
Benatti BB / 2009 / Inflammatory and bone-related genes are modulated by aging in human periodontal ligament cells / Cytokine 46 : 176 ~ 181
Doherty TM / 2003 / Calcification in atherosclerosis: bone biology and chronic inflammation at the arterial crossroads / Proc Natl Acad Sci U S A 100 : 11201 ~ 11206
Gilbert L / 2002 / Expression of the osteoblast differentiation factor RUNX2 (Cbfa1/AML3/Pebp2alpha A) is inhibited by tumor necrosis factor- alpha / J Biol Chem 277 : 2695 ~
Ji H / 2002 / Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis / J Exp Med 196 : 77 ~ 85
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