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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제6호
- 발행연도
- 2008.1
- 수록면
- 1,197 - 1,202 (6page)
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Recent studies provide some evidence that the HtrA2 protein is intimately associated with the pathogenesis of neurodegenerative disorders and that endoplasmic reticulum (ER) quality control and ER stress-associated cell death play critical roles in neuronal cell death. However, little is known about the intimate relationship between HtrA2 and ER stress-associated cellular responses. In the present study, we have demonstrated that the HtrA2 protein level was gradually and significantly increased by up to 10-fold in the mitochondria under tunicamycin (Tm)-induced ER stress, which eventually promoted cell death through the release of HtrA2 into the cytoplasm. Using an ecdysoneinducible mammalian expression system, we demonstrate that the extent of cell death in 293-HtrA2 cells was approximately 20 times higher under Tm-induced ER stress, indicating that the increase in the HtrA2 protein level in the mitochondria itself is necessary but not sufficient for the promotion of cell death. Taken together, these results suggest that HtrA2 may serve as a mediator of ER stress-induced apoptosis and ER-mitochondrial cross-talk in some cellular processes.
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참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)]
Bertolotti, A. / 2000 / Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat / Cell Biol 2 : 326 ~ 332
Boya, P. / 2002 / Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization / Cell Death Differ 9 : 465 ~ 467
Danial, N. N. / 2004 / Cell death: Critical control points / Cell 116 : 205 ~ 219
Egger, L. / 2003 / Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions / Cell Death Differ 10 : 1188 ~ 1203
Bertolotti, A. / 2000 / Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response. Nat / Cell Biol 2 : 326 ~ 332
Boya, P. / 2002 / Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization / Cell Death Differ 9 : 465 ~ 467
Danial, N. N. / 2004 / Cell death: Critical control points / Cell 116 : 205 ~ 219
Egger, L. / 2003 / Serine proteases mediate apoptosis-like cell death and phagocytosis under caspase-inhibiting conditions / Cell Death Differ 10 : 1188 ~ 1203
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