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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
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- 학술저널
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- 2017.1
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Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues, contributing to the development of metabolic diseases. CD36 is a major mediator of cellular FFA uptake. Inside the cell, saturated FFAs are able to induce the production of cytosolic and mitochondrial reactive oxygen species (ROS), which can be prevented by co-exposure to unsaturated FFAs. There are close connections between oxidative stress and organellar Ca2+ homeostasis. Highly oxidative conditions induced by palmitate trigger aberrant endoplasmic reticulum (ER) Ca2+ release and thereby deplete ER Ca2+ stores. The resulting ER Ca2+ deficiency impairs chaperones of the protein folding machinery, leading to the accumulation of misfolded proteins. This ER stress may further aggravate oxidative stress by augmenting ER ROS production. Secondary to ER Ca2+ release, cytosolic and mitochondrial matrix Ca2+ concentrations can also be altered. In addition, plasmalemmal ion channels operated by ER Ca2+ depletion mediate persistent Ca2+ influx, further impairing cytosolic and mitochondrial Ca2+ homeostasis. Mitochondrial Ca2+ overload causes superoxide production and functional impairment, culminating in apoptosis. This vicious cycle of lipotoxicity occurs in multiple tissues, resulting in β-cell failure and insulin resistance in target tissues, and further aggravates diabetic complications.
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참고문헌 (21)
참고문헌 신청
Abumrad NA / 1993 / Cloning of a rat adipocyte membrane protein implicated in binding or transport of long-chain fatty acids that is induced during preadipocyte differentiati
Charles MA / 1997 / The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects : results of the Paris Prospective Study / Diabetol
Choi CS / 2007 / Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin r
Coburn CT / 2000 / Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice / J Biol Chem 275 : 32523 ~ 32529
Endemann G / 1993 / CD36 is a receptor for oxidized low density lipoprotein / J Biol Chem. 268 : 11811 ~ 11816
Charles MA / 1997 / The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects : results of the Paris Prospective Study / Diabetol
Choi CS / 2007 / Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin r
Coburn CT / 2000 / Defective uptake and utilization of long chain fatty acids in muscle and adipose tissues of CD36 knockout mice / J Biol Chem 275 : 32523 ~ 32529
Endemann G / 1993 / CD36 is a receptor for oxidized low density lipoprotein / J Biol Chem. 268 : 11811 ~ 11816
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