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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 163 - 173 (11page)
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초록· 키워드
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Flavonoid myricetin, usually found in tea and medicinal plants, has antioxidant and anti-inflammatory effects. Our objectives in this study were to verify the effects of myricetin on periodontal ligament fibroblasts (PDLFs) under inflammatory conditions and to observe its effects on osteoclast generation and on cytokine expression in RAW264.7 cells. To determine the effects of myricetin on PDLFs, we examined the expression and activity of proteolytic enzymes, including MMP-1, MMP-2, and MMP-8, which all play an important role in chronic periodontitis. We observed the effects of myricetin on intracellular signal transduction to verify the molecular mechanism involved. By measuring the formation of TRAP?positive multinucleated cells and the expression and activity of MMP-8, we were able to assess the effects of myricetin on osteoclast generation. In addition, by measuring the secretion of IL-6 and NO, we could evaluate the effects of myricetin on inflammatory mediators. We found that Myricetin had no effect on the viability of the PDLFs in the presence of inflammation, but it did decrease both the expression of MMP-1 and MMP-8 and the enzyme activity of MMP-2 and MMP-8 in these fibroblasts. Myricetin also decreased the lipopolysaccharide-stimulated phosphorylation of JNK, p38 signaling, IKKB, AKT, and p65RelA in the PDLFs. In the RAW264.7 cells, myricetin inhibited both the expression and the activity of MMP-8. Furthermore, Myricetin not only suppressed the generation of LPS-stimulated osteoclasts, but it also slightly inhibited LPS-stimulated degradation of IkB and decreased the release of LPS-induced IL-6 and NO. These findings suggest that myricetin alleviates the tissue-destructive processes that occur during periodontal inflammation.
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참고문헌 (23)
참고문헌 신청
J. W. Costerton / 1999 / Bacterial Biofilms: A Common Cause of Persistent Infections / Science 284(5418):1318~1322
R. C. V. Casarin / 2010 / Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis / Journal of Periodontal Research 45(5):635~642
Diya Zhang / 2008 / Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS / Innate Immunity 14(2):99~107
P. P. C. Souza / 2010 / Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2 / Journal of Dental Research 89(8):802~807
Julian M.W. Quinn / 2005 / Modulation of osteoclast formation / Biochemical and Biophysical Research Communications 328(3):739~745
R. C. V. Casarin / 2010 / Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis / Journal of Periodontal Research 45(5):635~642
Diya Zhang / 2008 / Lipopolysaccharide (LPS) of Porphyromonas gingivalis induces IL-1beta, TNF-alpha and IL-6 production by THP-1 cells in a way different from that of Escherichia coli LPS / Innate Immunity 14(2):99~107
P. P. C. Souza / 2010 / Stimulation of IL-6 Cytokines in Fibroblasts by Toll-like Receptors 2 / Journal of Dental Research 89(8):802~807
Julian M.W. Quinn / 2005 / Modulation of osteoclast formation / Biochemical and Biophysical Research Communications 328(3):739~745
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