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- 학술저널
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제19권 제10호
- 발행연도
- 2009.1
- 수록면
- 1,197 - 1,200 (4page)
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The whitening effect, tyrosinase inhibition, and cytotoxicity
of neoagarotetraose were measured after its purification
from hydrolyzed agar by gel filtration chromatography.
In melanoma B16F10 cells, the melanin content of
neoagarotetraose-treated cells was the same as that treated
by kojic acid or arbutin. In addition, tyrosinase of melanoma
cells was strongly inhibited by neoagarotetraose at a
concentration of 1 μg/ml and similarly inhibited at 10 and
100 μg/ml compared with those by arbutin or kojic acid. The
activity of mushroom tyrosinase showed a 38% inhibition by
neoagarotetraose at 1 μg/ml, and this inhibitory effect was
more efficient than that by kojic acid. Neoagarotetraose
revealed a similar IC50 (50% inhibition concentration)
value for mushroom tyrosinase as that by kojic acid.
These data suggest that the neoagarotetraose generated
from agar by recombinant β-agarase might be a good
candidate as a cosmetic additive for the whitening effect.
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참고문헌 (11)
참고문헌 신청
Briganti, S. / 2003 / Chemical and instrumental approaches to treat hyperpigmentation / Pigment Cell Res 16 : 101 ~ 110
Hera, Y. / 1997 / Reducing tyrosinase activity. US Patent 5670154
Ishihara, Y. / 1991 / Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity / J. Antibiot 44 : 25 ~ 3
Kadekaro, A. L. / 2003 / Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival / Ann. N. Y. Acad. Sci 994 : 359
Kobayashi, R. / 1997 / Neoagarobiose as a novel moisturizer with whitening effect / Biosci. Biotechnol. Biochem 61 : 162 ~ 163
Hera, Y. / 1997 / Reducing tyrosinase activity. US Patent 5670154
Ishihara, Y. / 1991 / Melanostatin, a new melanin synthesis inhibitor. Production, isolation, chemical properties, structure and biological activity / J. Antibiot 44 : 25 ~ 3
Kadekaro, A. L. / 2003 / Significance of the melanocortin 1 receptor in regulating human melanocyte pigmentation, proliferation, and survival / Ann. N. Y. Acad. Sci 994 : 359
Kobayashi, R. / 1997 / Neoagarobiose as a novel moisturizer with whitening effect / Biosci. Biotechnol. Biochem 61 : 162 ~ 163
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