지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제5호
- 발행연도
- 2005.1
- 수록면
- 913 - 918 (6page)
이용수
초록· 키워드
오류제보하기
agent against Gram (+) and Gram (-) bacteria. Its clinicalaplication has recently been limited, due to severe sideeffects such as bone marow suppression and aplastic anemia.In the present study, the cytoxic effects of chloramphenicolwere investigated in vitro using chronic myelogenous leukemiaK562 cels. Chloramphenicol inhibited the growth of K562cels in a dose-dependent manner, but their growth wasreversible cytotoxic effects. The expression of cel cycleregulatory molecules, including E2F-1 and cyclin D1, wasdecreased at the translational and/or transcriptional level afterbeing treated with a therapeutic blod level (20g/ml) ofchloramphenicol. Chloramphenicol also induced apoptotic celldeath through a caspase-dependent pathway, which was verifiedby Western blot analysis and the enzymatic activity ofinhibited the cel growth through aresting the transition of thecell cycle, and induced apoptotic cell death through a caspase-dependent pathway at therapeutic concentrations.
목차
등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Abou-Khalil, S / 1980 / Differential effects of chloramphenicol and its nitroso analogue on protein synthesis and oxidative phosphorylation in rat liver mitochondria / Bioche
Cardoso, M. C / 1993 / Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication / C
Firkin, F. C / 1968 / Differential effects of chloramphenicol on the growth and respiration of mammalian cells / Biochem. Biophys. Res. Commun. 32 : 398 ~ 402
Goh, K / 1979 / Chloramphenicol and chromosomal morphology / J. Med. 10 : 159 ~ 166
Gong, J / 1994 / A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry / Anal. Biochem. 218 : 314 ~ 319
Cardoso, M. C / 1993 / Reversal of terminal differentiation and control of DNA replication: Cyclin A and cdk2 specifically localize at subnuclear sites of DNA replication / C
Firkin, F. C / 1968 / Differential effects of chloramphenicol on the growth and respiration of mammalian cells / Biochem. Biophys. Res. Commun. 32 : 398 ~ 402
Goh, K / 1979 / Chloramphenicol and chromosomal morphology / J. Med. 10 : 159 ~ 166
Gong, J / 1994 / A selective procedure for DNA extraction from apoptotic cells applicable for gel electrophoresis and flow cytometry / Anal. Biochem. 218 : 314 ~ 319
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Molecular Cloning and Characterization of Two Major Endoglucanases from Penicillium decumbens
Journal of Microbiology and Biotechnology
2010 .01
-
Roles of Carbohydrate-Binding Module (CBM) of an Endo-β-1,4- Glucanase (Cel5L) from Bacillus sp. KD1014 in Thermostability and Small-Substrate Hydrolyzing Activity
Journal of Microbiology and Biotechnology
2018 .01
-
Trichostatin A Induces Apoptotic Cell Death in Human Breast Carcinoma Cells through Activation of Caspase-3
Journal of Life Science
2000 .10
-
복분자의 유방암 세포 사멸 및 사멸 유전자 발현 유도 효과
동아시아식생활학회지
2013 .12
-
Apoptotic Signaling Cascade of 5-aminolaevulinic Acid-based Photodynamic Therapy in Human Promyelocytic Leukemia HL-60 Cells
Journal of photoscience : an international journal officail organ of the korean society of photoscience
2002 .01
-
Comparative binding of antitumor drugs to DNA containing the telomere repeat sequence
Experimental and Molecular Medicine
2002 .01
-
Selective Overproduction of Chloramphenicol Acetyltransferase in the T7 Expression System
미생물학회지
1989 .12
-
만성 골수성 백혈병 세포주에서 As2O3가 세포주기 및 세포고사에 미치는 영향
대한임상검사과학회지
2006 .01
-
Neural cell adhesion molecule(NCAM) promotes the differentiation of hippocampal precursor cells to a neuronal lineage, especially to a glutamatergic neural cell type
Experimental and Molecular Medicine
2002 .01
-
Constitutive expression of 4-1BB on T cells enhances CD4+ T cell responses
Experimental and Molecular Medicine
2003 .01
-
Cell Death and Bacterial Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2013 .06
-
Cloning and Characterization of Cellulase Gene (cel5C) from Cow Rumen Metagenomic Library
생명과학회지
2012 .04
-
Expression of hOGG1 protein during differentiation of HL-60 cells
Experimental and Molecular Medicine
2003 .01
-
Quercetin Prevents Hydrogen Peroxide-induced Necrotic and Apoptotic Cell Death in Human Colonic Epithelial Cells
대한임상검사과학회지
2011 .01
-
Methyl-beta-cyclodextrin inhibits cell growth and cell cycle arrest via a prostaglandin E(2) independent pathway
Experimental and Molecular Medicine
2004 .01
-
Anti-apoptotic role of phospholipase D isozymes in the glutamate-induced cell death
Experimental and Molecular Medicine
2003 .01
-
The Cytotoxic and Apoptotic Effect of Pseudomonas aeruginosa Exotoxin A on Human Leukemia K-562 Cells
대한임상검사과학회지
2007 .01
-
Resveratrol derivatives potently induce apoptosis in human promyelocytic leukemia cells
Experimental and Molecular Medicine
2003 .01
-
Ceramide-Induced Apoptotic Cell Death in Mouse Granulosa Cells
한국동물학회 학술대회
1997 .01
-
Cell Cycle Arrest and Cytochrome c-mediated Apoptotic Induction in A549 Human Lung Cancer Cells by MCS-C2, an Analog of Sangivamycin
Journal of Microbiology and Biotechnology
2010 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0