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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제26권 제1호
- 발행연도
- 2016.1
- 수록면
- 66 - 71 (6page)
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PikD is a widely known pathway-specific regulator for controlling pikromycin production in Streptomyces venezuelae ATCC 15439, which is a representative of the large ATP-binding regulator of the LuxR family (LAL) in Streptomyces sp. RapH and FkbN also belong to the LAL family of transcriptional regulators, which show greatest homology with the ATP-binding motif and helix-turn-helix DNA-binding motif of PikD. Overexpression of pikD and heterologous expression of rapH and fkbN led to enhanced production of pikromycin by approximately 1.8-, 1.6-, and 1.6-fold in S. venezuelae, respectively. Cross-complementation of rapH and fkbN in the pikD deletion mutant (ΔpikD) restored pikromycin and derived macrolactone production. Overall, these results show that heterologous expression of rapH and fkbN leads to the overproduction of pikromycin and its congeners from the pikromycin biosynthetic pathway in S. venezuelae, and they have the same functionality as the pathwayspecific transcriptional activator for the pikromycin biosynthetic pathway in the ΔpikD strain. These results also show extensive “cross-communication” between pathway-specific regulators of streptomycetes and suggest revision of the current paradigm for pathwayspecific versus global regulation of secondary metabolism in Streptomyces species.
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참고문헌 (14)
참고문헌 신청
Biermam M / 1992 / Plasmids cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp / Gene 116:43~49
Huang J / 2005 / Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor / Mol. Microbiol 58:1276~1287
Jung WS / 2008 / Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae / Appl. Environ. Microbiol 74:1972~1979
Kieser T / 2000 / Practical Streptomyces Genetics / John Innes Foundation
Kitani S / 2009 / Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis / Appl. Microbiol. Biotechnol 82:1089~1096
Huang J / 2005 / Cross-regulation among disparate antibiotic biosynthetic pathways of Streptomyces coelicolor / Mol. Microbiol 58:1276~1287
Jung WS / 2008 / Enhanced heterologous production of desosaminyl macrolides and their hydroxylated derivatives by overexpression of the pikD regulatory gene in Streptomyces venezuelae / Appl. Environ. Microbiol 74:1972~1979
Kieser T / 2000 / Practical Streptomyces Genetics / John Innes Foundation
Kitani S / 2009 / Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis / Appl. Microbiol. Biotechnol 82:1089~1096
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