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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제20권 제8호
- 발행연도
- 2010.1
- 수록면
- 1,192 - 1,195 (4page)
이용수
초록· 키워드
오류제보하기
To investigate the influence of the N- or C-terminal regions of pleurocidin (Ple) peptide on antifungal activity,four analogs partially truncated in the N- or C-terminal regions were designed and synthesized. Circular dichroism (CD) spectroscopy demonstrated that all the analogs maintained an alpha-helical structure. The antifungal susceptibility testing also showed that the analogs exhibited antifungal activities against human fungal pathogens,without hemolytic effects against human erythrocytes. The result further indicated that the analogs had discrepant antifungal activities [Ple>Ple (1-22)>Ple (4-25)>Ple (1-19)>Ple (7-25)] and that N-terminal deletion affected the activities much more than C-terminal deletion.
Hydrophobicity [Ple>Ple (1-22)>Ple (4-25)>Ple (1-19)>Ple (7-25)] was thought to have been one of the consistent factors that influenced these activity patterns, rather than the other primary factors like the helicity [Ple>Ple (4-25)>Ple (1-22)>Ple (1-19)>Ple (7-25)] or the net charge [Ple=Ple (4-25)=Ple (7-25)>Ple (1-22)=Ple (1-19)] of the peptides. In conclusion, the hydrophobic amino acids in the N-terminal region of Ple is more crucial for antifungal activity than those in the C-terminal region.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Albertson, G. D / 1996 / Multiple efflux mechanisms are involved in Candida albicans fluconazole resistance / Antimicrob. Agents Chemother 40 : 2835 ~ 2841
Amichai, B / 1998 / Adverse drug reactions of the new oral antifungal agents - terbinafine, fluconazole, and itraconazole / Int. J. Dermatol 37 : 410 ~ 415
Cole, A. M / 1997 / Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder / J. Biol. Chem 272 : 12008 ~ 12013
Dathe, M / 1999 / Structural features of helical antimicrobial peptides: Their potential to modulate activity on model membranes and biological cells / Biochim. Biophys. Acta
Habermann, E / 1972 / Bee and wasp venoms / Science 177 : 314 ~ 322
Amichai, B / 1998 / Adverse drug reactions of the new oral antifungal agents - terbinafine, fluconazole, and itraconazole / Int. J. Dermatol 37 : 410 ~ 415
Cole, A. M / 1997 / Isolation and characterization of pleurocidin, an antimicrobial peptide in the skin secretions of winter flounder / J. Biol. Chem 272 : 12008 ~ 12013
Dathe, M / 1999 / Structural features of helical antimicrobial peptides: Their potential to modulate activity on model membranes and biological cells / Biochim. Biophys. Acta
Habermann, E / 1972 / Bee and wasp venoms / Science 177 : 314 ~ 322
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