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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제16권 제4호
- 발행연도
- 2006.1
- 수록면
- 576 - 583 (8page)
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The alkali-soluble glucan of the yeast cell walcontains β-(1,3)- and (1,6)-D-linkages and is known tosystemically enhance the imune system. In the previousstudy [6], in order to isolate cell wall mutants, a wild-typethe mutants were then selected via treatment with laminarinase(endo-β-(1,3)-D-glucanase). The mas of alkali- and water-soluble glucans produced by the mutant was measured to be33.8 mg/g of the dry mas of the yeast cel. Our resultsshowed that the mutants generated the amount of alkali-soluble glucan 10-fold higher than that generated by the wild-type. Structural analysis showed that the alkali-soluble glucanfrom the mutants was associated with a higher degree of β-(1,6)-Dwild-type. Yeast cell wall β-glucan was shown to interact withmacrophages via receptors, thereby inducing the release oftumor necrosis factor alpha (TNF-α) and nitric oxide. Alkali-soluble β-glucans, both from water-soluble and water-insolubleglucan, exhibited a higher degree of macrophage activity withregard to both the secretion of tumor necrosis factor alpha(TNF-α) and nitric oxide and direct phagocytosis, than didthe positive control (1g of lipopolysaccharide).
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참고문헌 (22)
참고문헌 신청
Chorvatovicova J. Sandula / 1999 / Protective effect of the yeast glucomannan against cyclophosphamideinduced mutagenicity / Mutat. Res. 444 : 117 ~ 122
Czop, J. K / 1991 / Isolation and characterization of glucan receptors on human mononuclear phagocytes / J. Exp. Med. 173 : 1511 ~ 1518
Ding, A. H / 1988 / Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evi
Esteban, A / 2004 / Glucan receptor but not mannose receptor is involved in the phagocytosis of Saccharomyces cerevisiae by seabream (Sparus aurata L.) blood leucocytes / Fis
Fleet, G. H / 1976 / Isolation and composition of an alkali-soluble glucan from the cell walls of Saccharomyces / J. Gen. Microbiol. 94 : 180 ~ 192
Czop, J. K / 1991 / Isolation and characterization of glucan receptors on human mononuclear phagocytes / J. Exp. Med. 173 : 1511 ~ 1518
Ding, A. H / 1988 / Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evi
Esteban, A / 2004 / Glucan receptor but not mannose receptor is involved in the phagocytosis of Saccharomyces cerevisiae by seabream (Sparus aurata L.) blood leucocytes / Fis
Fleet, G. H / 1976 / Isolation and composition of an alkali-soluble glucan from the cell walls of Saccharomyces / J. Gen. Microbiol. 94 : 180 ~ 192
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