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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제9호
- 발행연도
- 2007.1
- 수록면
- 1,513 - 1,520 (8page)
이용수
초록· 키워드
오류제보하기
β-1,3-Glucans enhance imune reactions such asantitumor, antibacterial, antiviral, anticoagulatory, and woundhealing activities. β-1,3-Glucans have various functions dependingwater solubility, and intermolecular association. The molecularweight of the soluble glucan was about 15,000 as determinedby a high-performance size exclusion chromatography. Fromthe infrared (IR) and 13C NMR analytical data, the purifiedsoluble glucan was found to exclusively consist of β-D-glucopyranose with 1,3 linkage. We tested the immune-stimulating activities of the soluble β-1,3-glucan extractedfrom Agrobacteriumfollowing activities. IFN-γ and each cytokines were inducedin the spleens and thymus of mice treated with soluble β-1,3-glucan. Adjuvant effect was observed on antibody production.Nitric oxide was synthesized in monocytic cell lines treatedwith β-1,3-glucan. The cytotoxic and antitumor effects wereobserved on various cancer cell lines and ICR mice. Theseresults strongly suggested that this soluble β-1,3-glucan couldbe a good candidate for an immune-modulating agent.
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참고문헌 (29)
참고문헌 신청
/ 1991 / Macrophage NO2-production as a sensitive and rapid assay for the quantitation of murine IFN-γ immu (l) : 107 ~ 139 114
Bohn, J. / 1995 / (1→3)-β-Glucans as biological response modifiers: A review of structurefunctional activity relat 28 : 3 ~ 14
Cheung, N / 2002 / Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies 51 : 557 ~ 564
Cho, Y / 2000199-206 / Development of screening systems for drugs against human papillomavirus-associated cervical cancer: Based on E6- E6AP binding 47 : 199 ~ 206
Colle, J / 1997 / Quantitation of messenger RNA by competitive RTPCR: A simplified read out assay 210 : 175 ~ 184
Bohn, J. / 1995 / (1→3)-β-Glucans as biological response modifiers: A review of structurefunctional activity relat 28 : 3 ~ 14
Cheung, N / 2002 / Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies 51 : 557 ~ 564
Cho, Y / 2000199-206 / Development of screening systems for drugs against human papillomavirus-associated cervical cancer: Based on E6- E6AP binding 47 : 199 ~ 206
Colle, J / 1997 / Quantitation of messenger RNA by competitive RTPCR: A simplified read out assay 210 : 175 ~ 184
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