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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제18권 제2호
- 발행연도
- 2008.1
- 수록면
- 369 - 376 (8page)
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초록· 키워드
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In the present study, we investigated the radioprotective effect of cyclo(L-phenylalanyl-L-prolyl) on irradiated rat lungs to determine its potential as a radioprotective agent.
We found that early lung damage induced by irradiation was reduced by treatment with 40 mg/kg of cyclo(Lphenylalanyl- L-prolyl) in the latent and early pneumonitis phases. Expression of TNF-α and TGF-β1 at 2 and TGF- β1 at 8 weeks post-irradiation was decreased in animals that received both radiation and cyclo(L-phenylalanyl-Lprolyl) compared with animals that received radiation alone. Evidence indicated that the proinflammatory cytokine TNF-α and the fibrogenic cytokine TGF-β1 likely play a role in the radioprotective effect of cyclo(L-phenylalanyl- L-prolyl). However, besides TNF-α and TGF-β1 expressions, the precise mechanism by which cyclo(L-phenylalanyl-L-prolyl) ameliorates the induced radiation damage is not clear.
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참고문헌 (21)
참고문헌 신청
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Brand-Williams, W. / 1995 / Use of a free radical method to evaluate antioxidant activity. Lebensm. Wiss / Technol 28 : 25 ~ 30
Brandes, M. E. / 1990 / The production of alveolar macrophage-derived growth-regulating proteins in response to lung injury. Toxicol / Lett 54 : 3 ~ 22
Chen, Y. S. / 1960 / Studies on the metabolic products of Rosellinia necatrix. I. Isolation and characterization of several physiologically active neutral substances. Bull. A
Cohen, E. P. / 1996 / Captopril preserves function and ultrastructure in experimental radiation nephropathy. Lab / Investig 75 : 349 ~ 360
Brand-Williams, W. / 1995 / Use of a free radical method to evaluate antioxidant activity. Lebensm. Wiss / Technol 28 : 25 ~ 30
Brandes, M. E. / 1990 / The production of alveolar macrophage-derived growth-regulating proteins in response to lung injury. Toxicol / Lett 54 : 3 ~ 22
Chen, Y. S. / 1960 / Studies on the metabolic products of Rosellinia necatrix. I. Isolation and characterization of several physiologically active neutral substances. Bull. A
Cohen, E. P. / 1996 / Captopril preserves function and ultrastructure in experimental radiation nephropathy. Lab / Investig 75 : 349 ~ 360
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