지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 514 - 523 (10page)
이용수
초록· 키워드
오류제보하기
TGF-β1-induced glomerular mesangial cell (GMC) in-jury is a prominent characteristic of renal pathology in several kidney diseases, and a ternary protein com-plex consisting of PINCH-1, integrin-linked kinase (ILK) and α-parvin plays a pivotal role in the regulation of cell behavior such as cel proliferation and hyper-trophy. We report here that PINCH-1-ILK-α-parvin (PIP) complex regulates the TGF-βliferation and hypertrophy in cultured rat GMCs. When GMCs were treated with TGF-β1 for 1, 2 and 3 days, the PIP complex formation was up-regulated after 1 day, but it was down-regulated on day 2. Cell numbers were significantly elevated on day 2, but dramatically decreased on day 3. In contrast, a sig-nificant increase in cellular protein contents was ob-served 3 days after TGF-β1-treatment. TGF-β1 in-duced early increase of caspase-3 activity. In GMCs β1 for 2 days, cytosolic ex-pression of p27Kip1 was dramatically reduced, but its nuclear expression was remarkably elevated. A sig-nificantly decreased expression of phospho-Akt (Ser 473) was observed in the cells treated with TGF-β1 for 1 day. TGF-β1 induced early increase of phos-pho-p27Kip1(Thr 157) expression with subsequent de-crease, and similar responses to TGF-β1 were ob-Taken together, TGF-β1 differently regulates the PIP complex formation of GMCs in an incubation peri-od-dependant fashion. The TGF-β1-induced up- and down-regulation of the PIP complex formation likely contributes to the pleiotropic efects of TGF-β1 on mesangial cell proliferation and hypertrophy through cellular localization of p27Kip1and alteration of Akt and p38 phosphorylation. TGF-β1-induced alteration implicated in the development and progression of glomerular failure shown in several kidney diseases.
목차
등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
[학
Bak M / 2000 / Renal enlargement precedes renal hyperfiltration in early ex-perimental diabetes in rats 1 : 1287 ~ 1292
Blagosklonny MV / 2002 / Are p27 and p21 cytoplasmic oncopro-teins? 1 : 391 ~ 393
Bottinger EP / 2002 / TGF-β signaling in renal disease 13 : 2600 ~ 2610
Caruccio L / 1999 / An efficient method for simultaneous isolation of biologically active transcription factors and DNA 230 : 1 ~ 10
Bak M / 2000 / Renal enlargement precedes renal hyperfiltration in early ex-perimental diabetes in rats 1 : 1287 ~ 1292
Blagosklonny MV / 2002 / Are p27 and p21 cytoplasmic oncopro-teins? 1 : 391 ~ 393
Bottinger EP / 2002 / TGF-β signaling in renal disease 13 : 2600 ~ 2610
Caruccio L / 1999 / An efficient method for simultaneous isolation of biologically active transcription factors and DNA 230 : 1 ~ 10
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Kinetics and Biological Function of Transforming Growth Factor-β Isoformsin Bovine and Human Colostrum
Journal of Microbiology and Biotechnology
2004 .01
-
Expression and Activation of Transforming Growth Factor-Beta 2 in Cultured Bone Cells
Korean journal of biological sciences
2000 .01
-
TGF-β1 suppresses CCL3/4 expression through the ERK signaling pathway and inhibits intervertebral disc degeneration and inflammation-related pain in a rat model
Experimental and Molecular Medicine
2017 .01
-
TGF-β3는 마우스 IgA, IgG2b 항체의 선택적 유도작용
미생물학회지
1999 .06
-
EpH4 세포에서 TGF-β에 의한 세포사멸시 Smad 단백질에 의존한 Gadd45b 유전자의 발현 변화
생명과학회지
2008 .04
-
TGF-β1 induces mouse dendritic cells to express VEGF and its receptor (Flt-1) under hypoxic conditions
Experimental and Molecular Medicine
2010 .01
-
Downregulation of SGK1 Expression is Critical for TGF-β-induced Apoptosis in Mouse Hepatocytes Cells
생명과학회지
2012 .11
-
INTRODUCTION OF NUTATED TGF-$\beta$1 cDNA CONFERS MACROPHAGE TO SECRETE AN ACTIVE FORM OF TGF- $\beta$1
한국동물학회 학술대회
1996 .01
-
Different role of Gadd45b in TGF-β and Fas-induced apoptosis
한국생명과학회 심포지움
2005 .04
-
Characterization of Apoptosis Induced by Transforming Growth Factor-$\beta$1(TGF-$\beta$1_ in Human Gastric Cancer Cells
한국동물학회 학술대회
1996 .01
-
TGF-β1 induces VEGF expression in human granulosa-lutein cells: a potential mechanism for the pathogenesis of ovarian hyperstimulation syndrome
Experimental and Molecular Medicine
2020 .01
-
PKC and Calcium Influx Mediate TGF-induced increase in IgA Production
한국동물학회 학술대회
1997 .01
-
TGF-β1 Expression by Proliferated Keratinocytes in the Skin of E-Irradiated Mice
생명과학회지
2012 .02
-
Synovial fluid of patients with rheumatoid arthritis induces α-smooth muscle actin in human adipose tissue-derived mesenchymal stem cells through a TGF-β1-dependent mechanism
Experimental and Molecular Medicine
2010 .01
-
사염화탄소 투여 쥐에서 아연이 간세포의 아포토시스와 TGF-ßl 분비에 미치는 영향
대한임상검사과학회지
2002 .01
-
HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-b1
Experimental and Molecular Medicine
2005 .01
-
Insulin resistance mediates high-fat diet-induced pulmonary fibrosis and airway hyperresponsiveness through the TGF-β1 pathway
Experimental and Molecular Medicine
2019 .01
-
고혈당으로 유도된 신장 mesangial cell에서 nobiletin의 matrix accumulation과 TGF-β1-Src-caveolin-1 signaling에 의한 사구체 경화증 억제효과
Journal of Nutrition and Health
2020 .02
-
Regulation of anti-inflammatory cytokines IL-10 and TGF-b in mouse dendritic cells through treatment with Clonorchis sinensis crude antigen
Experimental and Molecular Medicine
2014 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0