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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제17권 제6호
- 발행연도
- 2007.1
- 수록면
- 1,036 - 1,040 (5page)
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초록· 키워드
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Sodium butyrate (NaBu) has been used to enhanceprotein expresion levels in mamalian cell culture. Todetermine the clonal variability of recombinant Chinese hamsterovary (rCHO) cels in response to NaBu adition regardingspecific antibody productivity (qAb), three rCHO clones weresubjected to diferent concentrations of NaBu. For all threclones, NaBu addition inhibited cell growth and decreasedthe enhancing effect of NaBu on qAb varied significantly amongthe clones. NaBu addition enhanced the antibody production ofonly one clone. RT-PCR analysis revealed that the changes inqAb correlated linearly with those of the mRNA transcriptionlevel. Thus, it was concluded that the diferent enhancingeffects of NaBu on protein expression in rCHO cell clonesresulted from their diferent mRNA transcription levels.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Bae, G. W / 2006 / High productivity of t-PA in CHO cells using hypoxia response element 16 : 695 ~ 703
Bae, S. W. / 2005 / Intracellular responses of antibody-producing H69K-NGD transfectoma subjected to hyperosmotic pressure 15 : 579 ~ 586
Chang, B. S / 1999 / NAcetylcysteine increases the biosynthesis of recombinant EPO in apoptotic Chinese hamster ovary cells in apoptotic Chinese hamster ovary cellsv 30 : 85
Chung.B. S / 2001 / Effect of sodium butyrate on glycosylation of recombinant erythropoietin 11 : 1087 ~ 1092
Cockett / 1990 / High-level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification : 662 ~ 667
Bae, S. W. / 2005 / Intracellular responses of antibody-producing H69K-NGD transfectoma subjected to hyperosmotic pressure 15 : 579 ~ 586
Chang, B. S / 1999 / NAcetylcysteine increases the biosynthesis of recombinant EPO in apoptotic Chinese hamster ovary cells in apoptotic Chinese hamster ovary cellsv 30 : 85
Chung.B. S / 2001 / Effect of sodium butyrate on glycosylation of recombinant erythropoietin 11 : 1087 ~ 1092
Cockett / 1990 / High-level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification : 662 ~ 667
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