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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제14권 제6호
- 발행연도
- 2004.1
- 수록면
- 1,333 - 1,337 (5page)
이용수
초록· 키워드
오류제보하기
Oxidants such as hydrogen peroxide are powerfulinducers of cell damage, ageing, and apoptosis. Since clusterin,a 75- 80 kDa mammalian glycoprotein, is frequently found tobe inducible in apoptotic cells and tissues, this study inquiredinto whether this would be a protective mechanism againstfurther cell death. The aim was to find out whetheroverexpression of clusterin could protect cells from oxidantinducedstress and apoptosis. To clarify this issue, wegenerated and analyzed stable cell lines expressing fusionproteins of a rat clusterin with an enhanced green fluorescentprotein (EGFP). When treated with varying concentrations ofhydrogen peroxides, clusterin transfectants indeed showedincreased resistance to apoptosis and exhibited a much highersurvival rate than mock-transfected cells. On the other hand,neither intracellular re-distribution nor local concentrationof clusterin-EGFP was observed, which leaves the questionopen about its anti-apoptotic mechanism. In conclusion, theoverexpression of clusterin provides a means for protectingcells against oxidative stress and subsequent cell death.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
A / 1989 / Induction of the TRPM-2gene in cells undergoing programmed death : 3473 ~ 3481
Davies / 1995 / Oxidative stress: The paradox ofaerobic life. 61 : 1 ~ 31
Davies / 1999 / The broad spectrum of responses tooxidants in proliferating cells A new paradigm for oxidativestress 48 : 41 ~ 47
Dumont, P / 2002 / Overexpression of apolipoprotein J in human fibroblastsprotects against cytotoxicity and premature senescenceinduced by ethanol and tert-butylhydroperoxide
Fritz / 1983 / whichinfluences cell-cell interactions in vitro : 1173 ~ 1188
Davies / 1995 / Oxidative stress: The paradox ofaerobic life. 61 : 1 ~ 31
Davies / 1999 / The broad spectrum of responses tooxidants in proliferating cells A new paradigm for oxidativestress 48 : 41 ~ 47
Dumont, P / 2002 / Overexpression of apolipoprotein J in human fibroblastsprotects against cytotoxicity and premature senescenceinduced by ethanol and tert-butylhydroperoxide
Fritz / 1983 / whichinfluences cell-cell interactions in vitro : 1173 ~ 1188
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