지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 124 - 129 (6page)
이용수
초록· 키워드
오류제보하기
The extraction and purification of the anti-hyperglycemic α-glucosidase inhibitor from an edible mushroom, Pleurotus cornucopiae, were investigated. The inhibitor was maximally extracted when the P. cornucopiae fruiting body was treated with distilled water at 30°C for 12 h. Purification was achieved using Sephadex G-100 and G-50 filtration chromatography, pepsin hydrolysis, and reverse-phase HPLC. The compound’s solid yield and inhibitory activity were 12.2% and 9.10 mg/ml of IC50, respectively. The purified inhibitor contained two hexapeptides with Thr-Ile-Ala-Phe-Ile-Asp (A) and Tyr-Tyr-Ala-Ile-Gly-Asp (B) sequences and molecular weights of 678.79 Da (A) and 643.7 Da (B). The purified inhibitor showed a mixed inhibition pattern to α-glucosidase and a dose-dependent anti-hyperglycemic effect in a streptozotocininduced diabetic Sprague-Dawley rat model, exhibited by decreased blood glucose levels at doses of 50 and 300 mg/kg.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Asano N / 1994 / N-containing sugars from Morus alba and their glycosidase inhibitory activities / Carbohydr. Res 259:243~255
Fatmawati S / 2011 / Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum / Phytomed 18:1053~1055
Gutiérrez A / 1994 / Anisaldehyde production and aryl-alcohol oxidase and dehydrogenase activities in ligninolytic fungi of the genus Pleurotus / Appl. Environ. Microbiol 60:1783~1788
Gern RM / 2008 / Alternative medium for production of Pleurotus ostreatus biomass and potential antitumor polysaccharides / Bioresour. Technol 99:76~82
허진주 / 2010 / Streptozotocin으로 유도된 당뇨 마우스에서 L-carnosine의 혈당강하 효과 / 대한수의학회지 50(2):105~111
Fatmawati S / 2011 / Ganoderol B: a potent α-glucosidase inhibitor isolated from the fruiting body of Ganoderma lucidum / Phytomed 18:1053~1055
Gutiérrez A / 1994 / Anisaldehyde production and aryl-alcohol oxidase and dehydrogenase activities in ligninolytic fungi of the genus Pleurotus / Appl. Environ. Microbiol 60:1783~1788
Gern RM / 2008 / Alternative medium for production of Pleurotus ostreatus biomass and potential antitumor polysaccharides / Bioresour. Technol 99:76~82
허진주 / 2010 / Streptozotocin으로 유도된 당뇨 마우스에서 L-carnosine의 혈당강하 효과 / 대한수의학회지 50(2):105~111
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
α-Glucosidase 저해물질을 함유한 노랑느타리버섯 (Pleurotus cornucopiae) 물추출물의 혈당상승 억제 효과
한국균학회지
2016 .01
-
잣버섯(Neolentinus lepideus) 에탄올 추출물의 혈당상승 억제 효과
한국균학회지
2015 .01
-
Screening of Potent Anti-dementia Acetylcholinesterase Inhibitor-containing Edible Mushroom Pholiota adiposa and the Optimal Extraction Conditions for the Acetylcholinesterase Inhibitor
한국균학회지
2016 .01
-
A Comprehensive Review of Tropical Milky White Mushroom (Calocybe indica P&C)
Mycobiology
2015 .01
-
α-Glucosidase Inhibitor Isolated from Coffee
Journal of Microbiology and Biotechnology
2015 .01
-
Increased Fungal Infections while using Emerging Therapies (Biologics and Small-molecule Inhibitors) for Treating Skin Diseases: A Review
대한의진균학회지
2021 .09
-
Upcycling the Spent Mushroom Substrate of the Grey Oyster Mushroom Pleurotus pulmonarius as a Source of Lignocellulolytic Enzymes for Palm Oil Mill Effluent Hydrolysis
Journal of Microbiology and Biotechnology
2021 .01
-
화살나무(Euonymus alatus)로 부터 α-glucosidase 저해 물질의 분리 및 동정
한국미생물·생명공학회지
2017 .01
-
The Effects of Different Substrates on the Growth, Yield, and Nutritional Composition of Two Oyster Mushrooms (Pleurotus ostreatus and Pleurotus cystidiosus)
Mycobiology
2015 .01
-
Structural mechanism of inhibitor-resistance by ERK2 mutations
Biodesign
2021 .01
-
Present status and prospect for development of mushrooms in Korea
한국균학회 학술대회
2018 .01
-
Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice
Nutrition Research and Practice
2016 .06
-
Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice
Nutrition Research and Practice
2016 .06
-
Effects of the DNA repair inhibitors, cytosine arabinoside and 3‑aminobenzamide, on the frequency of radiation‑induced micronuclei, nuclear buds, and nucleoplasmic bridges
Genes & Genomics
2020 .01
-
Characterization of β-Glucosidase Produced by the White Rot Fungus Flammulina velutipes
Journal of Microbiology and Biotechnology
2015 .01
-
신령버섯 자실체 메탄올 추출물의 항산화, 항당뇨 및 Nitric Oxide의 저해 효과
대한임상검사과학회지
2015 .01
-
The Effects of Temperature and Nutritional Conditions on Mycelium Growth of Two Oyster Mushrooms (Pleurotus ostreatus and Pleurotus cystidiosus)
Mycobiology
2015 .01
-
항당뇨 효능이 있는 천연물의 탐색 및 활성물질의 분석
생명과학회지
2023 .10
-
Crystal structure of the complex of DUSP15 and its inhibitor reveals novel inhibitor binding interactions
Biodesign
2019 .01
-
Enhancement of ${\beta}$-Glucosidase Activity from a Brown Rot Fungus Fomitopsis pinicola KCTC 6208 by Medium Optimization
Mycobiology
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0