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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 603 - 613 (11page)
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초록· 키워드
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Pigmentation may result from melanocyte proliferation,
melanogenesis, migration or increases in
dendricity. Recently, it has been reported that secreted
phospholipase A2 (sPLA2) known as a component of
bee venom (BV), stimulates melanocyte dendricity and
pigmentation. BV has been used clinically to control
rheumatoid arthritis and to ameliorate pain via its anti-
inflammatory and antinociceptive properties. Moreover,
after treatment with BV, pigmentation around the
injection sites was occasionally observed and the pigmentation
lasted a few months. However, no study has
been done about the effect of BV on melanocytes.
Thus, in the present study, we examined the effect of
BV on the proliferation, melanogenesis, dendricity and
migration in normal human melanocytes and its signal
transduction. BV increased the number of melanocytes
dose and time dependently through PKA, ERK,
and PI3K/Akt activation. The level of cAMP was also increased
by BV treatment. Moreover, BV induced melanogenesis
through increased tyrosinase expression.
Furthermore, BV induced melanocyte dendricity and migration through PLA2 activation. Overall, in this
study, we demonstrated that BV may have an effect on
the melanocyte proliferation, melanogenesis, dendricity
and migration through complex signaling pathways
in vitro, responsible for the pigmentation. Thus,
our study suggests a possibility that BV may be developed
as a therapeutic drug for inducing repigmentation
in vitiligo skin.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
/ / Marko O. Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin. Proc Natl Acad Sci USA 1982 : 1139 2018 ~ 22
/ 2007 / 612 Exp 39 (5) : 603 ~ 613
Akdis CA / 1996 / Epitope-specific T cell tolerance to phospho-lipase A2 in bee venom immunotherapy 98 : 1676 ~ 1683
Arita Y / / Weinstein IB. Growth of human melanocyte cultures supported by 12-O-tetradecano-ylphorbol-13-acetate is mediated through protein kinase C activation. Cancer Res 1
Bertolotto C / 1998 / Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) an
/ 2007 / 612 Exp 39 (5) : 603 ~ 613
Akdis CA / 1996 / Epitope-specific T cell tolerance to phospho-lipase A2 in bee venom immunotherapy 98 : 1676 ~ 1683
Arita Y / / Weinstein IB. Growth of human melanocyte cultures supported by 12-O-tetradecano-ylphorbol-13-acetate is mediated through protein kinase C activation. Cancer Res 1
Bertolotto C / 1998 / Different cis-acting elements are involved in the regulation of TRP1 and TRP2 promoter activities by cyclic AMP: pivotal role of M boxes (GTCATGTGCT) an
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