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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 313 - 319 (7page)
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초록· 키워드
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Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin content was accompanied by reduced tyrosinase enzyme activity, protein and mRNA expression. The levels of tyrosinase-related protein 1 and 2 mRNAs were decreased by XH. XH also inhibited α-melanocyte stimulating hormone- or forskolin-induced increases in melanogenesis, suggesting an action on the cAMP-dependent melanogenic pathway. XH downregulated the protein and mRNA expression of microphthalmia- associated transcription factor (MITF), a master transcriptional regulator of key melanogenic enzymes. These results suggest that XH might act as a hypo-pigmenting agent through the downregulation of MITF in the cAMP-dependent melanogenic pathway.
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참고문헌 (26)
참고문헌 신청
Beavo JA / 1970 / Effects of xanthine derivatives on lipolysis and on adenosine 3',5'-monophosphate phosphodiesterase activity / Mol Pharmacol 6 : 597 ~ 603
Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 2
Busca R / 2000 / Cyclic AMP a key messenger in the regulation of skin pigmentation / Pigment Cell Res 13 : 60 ~ 9
Cone RD / 1996 / The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation / Recent Prog Horm Res 51 : 287 ~ 317
Costin GE / 2007 / Human skin pigmentation: melanocytes modulate skin color in response to stress / Faseb J 21 : 976 ~ 94
Bradford MM / 1976 / A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding / Anal Biochem 72 : 2
Busca R / 2000 / Cyclic AMP a key messenger in the regulation of skin pigmentation / Pigment Cell Res 13 : 60 ~ 9
Cone RD / 1996 / The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation / Recent Prog Horm Res 51 : 287 ~ 317
Costin GE / 2007 / Human skin pigmentation: melanocytes modulate skin color in response to stress / Faseb J 21 : 976 ~ 94
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