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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 675 - 683 (9page)
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Graft-versus-host disease (GVHD) is mediated by mature donor T cells contained in the hematopoietic stem cell graft. During the development of GVHD, signaling through a variety of costimulatory receptors plays an important role in allogeneic T cell responses. Even though delivery of costimulatory signals is a prerequisite for full activation of donor T cells in the phase of their interactions with host APCs, their involvement with GVHD might occur over multiple stages. Like many other aspects of GVHD, promise of therapeutic interventions with costimulatory pathways has been gleaned from preclinical models. In this review, I summarize some of the advances in roles of costimulatory molecules in GVHD pathophysiology and discuss preclinical approaches that warrant further exploration in the clinic, focusing on novel strategies to delete pathogenic T cells.
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참고문헌 (21)
참고문헌 신청
Albert MH / 2005 / Prevention of lethal acute GVHD with an agonistic CD28 antibody and rapamycin / Blood 105 : 1355 ~ 1361
Anderson BE / 2005 / Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements
Beyersdorf N / 2005 / Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis / J Exp Med 202
Blazar BR / 1994 / In vivo blockade of CD28/CDTL4:B7/BB1 interaction with CTLA4 reduces lethal murine graft-versus-host disease across the major histocompatibility complex ba
Blazar BR / 1997 / Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone ma
Anderson BE / 2005 / Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements
Beyersdorf N / 2005 / Selective targeting of regulatory T cells with CD28 superagonists allows effective therapy of experimental autoimmune encephalomyelitis / J Exp Med 202
Blazar BR / 1994 / In vivo blockade of CD28/CDTL4:B7/BB1 interaction with CTLA4 reduces lethal murine graft-versus-host disease across the major histocompatibility complex ba
Blazar BR / 1997 / Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone ma
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