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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 94 - 99 (6page)
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초록· 키워드
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GITR (glucocorticoid-induced TNF receptor) is a recently identified member of the TNF receptor superfamily. The receptor is preferentially ex-pressed on CD4+CD25+regulatory T cells and GITR signals break the suppressive activity of the subset. In this study, we wanted to reveal the in vivo function of GITR in chronic graft-versus-host disease (cGVHD), a lupus-like autoimmune disease. A single injection of anti-GITR monoclonal antibody (DTA-1) was effective in blocking the progression of cGVHD in the parent-into-F1 model. Treatment of DTA-1 significantly decreased levels of IgG1 anti-DNA increased survival. The DTA-1-mediated inhibition of autoantibody production correlated with deletion of B cells and could occur independently of CD4+CD25+regulatory T cells. Our results indicate that anti-GITR monoclonal antibody may be used as a potential immunotherapeutic agent for preventing cGVHD.
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등록된 정보가 없습니다.
참고문헌 (8)
참고문헌 신청
/ / Attempts at standardization of lupus-like graft-vs-host disease: inadvertent repopulation by DBA/2 spleen cells of H-2 diferent nonirradiated F1 mice. (l)
/ 1999 / A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. 94 : 6216 ~ 21
/ 2000 / Revisiting graft-versus-host disease models of autoimmunity new insights in immune regulatory processes 106 : 745 ~ 7
/ 2002 / Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease 8 : 1405 ~ 13
/ 2002 / Stimulation of CD25+CD4+regulatory T cells through GITR breaks immunological self-tolerance 3 : 135 ~ 42
/ 1999 / A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. 94 : 6216 ~ 21
/ 2000 / Revisiting graft-versus-host disease models of autoimmunity new insights in immune regulatory processes 106 : 745 ~ 7
/ 2002 / Costimulatory molecule-targeted antibody therapy of a spontaneous autoimmune disease 8 : 1405 ~ 13
/ 2002 / Stimulation of CD25+CD4+regulatory T cells through GITR breaks immunological self-tolerance 3 : 135 ~ 42
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