지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 647 - 657 (11page)
이용수
초록· 키워드
오류제보하기
Curcumin (from the rhizome of Curcuma longa) is well
documented for its medicinal properties in Indian and
Chinese systems of medicine where it is widely used
for the treatment of several diseases. Epidemiological
observations are suggestive that curcumin consumption
may reduce the risk of some form of cancers
and provide other protective biological effects in
humans. These biological properties have been attributed
to curcuminoids that have been widely studied for
their anti-inflammatory, anti-angiogenic, antioxidant,
wound healing and anti-cancer effects. In this study we
have investigated on the effect of a curcumin phospholipid
complex on mammary epithelial cell viability.
HC11 and BME-UV cell lines, validated models to study
biology of normal, not tumoral, mammary epithelial
cells, were used to analyse these effects. We report that
curcumin acts on STAT-3 signal pathway to reduce cell
viability and increase apoptosis evaluated by the the
amount of activated caspase 3. Further it reduces
MAPK and AKT activations. JSI-124, a STAT-3 inhibitor
(100 nM) was able to block the negative effect of curcumin
on cell viability and caspase 3 activation. Finally
the negative effect of cucumin on cell viability has been
impaired in STAT-3i HC11, where STAT-3 protein was
greatly reduced by shRNA-interference. These results
indicate that curcumin presents a potential adverse effect
to normal mammary epithelial cells and that it has
a specific effect on signal trasduction in mammary
epithelium.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Aggarwal BB / 2003 / Anticancer potential of curcumin: preclinical and clinical studies / Anticancer Res 23 : 363 ~ 98
Baratta M / 2000 / Role of androgens in proliferation and differentiation of mouse mammary epithelial cell line HC11 / J Endocrinol 167 : 53 ~ 60
Blaskovich MA / 2003 / Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with pot
Chapman RS / 1999 / Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3 / Genes Dev 13 : 2604 ~ 16
Chapman RS / 2000 / The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3 / Adv Exp Med Biol 480 : 129 ~ 38
Baratta M / 2000 / Role of androgens in proliferation and differentiation of mouse mammary epithelial cell line HC11 / J Endocrinol 167 : 53 ~ 60
Blaskovich MA / 2003 / Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with pot
Chapman RS / 1999 / Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3 / Genes Dev 13 : 2604 ~ 16
Chapman RS / 2000 / The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3 / Adv Exp Med Biol 480 : 129 ~ 38
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Nutrition Research and Practice
2015 .04
-
Curcumin utilizes the anti-inflammatory response pathway to protect the intestine against bacterial invasion
Nutrition Research and Practice
2015 .04
-
Curcumin이 인체대장암세포주인 SW480 cell에서 세포사멸에 미치는 영향
한국영양학회지
2004 .01
-
Hypoxia activates signal transducers and activators of transcription 5 (STAT5) and increases its binding activity to the GAS element in mammary epithelial cells
Experimental and Molecular Medicine
2003 .01
-
Improved Anti-Cancer Effect of Curcumin on Breast Cancer Cells by Increasing the Activity of Natural Killer Cells
Journal of Microbiology and Biotechnology
2018 .01
-
Pretreatment of curcumin protects hippocampal neurons against excitotoxin-induced cell death
생명과학회지
2007 .01
-
Curcumin inhibits cellular condensation and alters microfilament organization during chondrogenic differentiation of limb bud mesenchymal cells
Experimental and Molecular Medicine
2009 .01
-
Estimation of curcumin intake in Korea based on the Korea National Health and Nutrition Examination Survey (2008-2012)
Nutrition Research and Practice
2014 .10
-
Estimation of curcumin intake in Korea based on the Korea National Health and Nutrition Examination Survey (2008-2012)
Nutrition Research and Practice
2014 .10
-
Synthesis of Curcumin Glycosides with Enhanced Anticancer Properties Using One-Pot Multienzyme Glycosylation Technique
Journal of Microbiology and Biotechnology
2017 .01
-
C57BL/6 마우스에서 고지방 식이와 CCl4로 유발한 간섬유증에 미치는 커큐민의 보호효과
대한임상검사과학회지
2015 .01
-
Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet
Nutrition Research and Practice
2010 .06
-
Hypocholesterolemic effects of curcumin via up-regulation of cholesterol 7a-hydroxylase in rats fed a high fat diet
Nutrition Research and Practice
2010 .06
-
Hypoxia activates the cyclin D1 promoter via the Jak2/STAT5b pathway in breast cancer cells
Experimental and Molecular Medicine
2005 .01
-
Curcumin reduces cold storage-induced damage in humancardiac myoblasts
Experimental and Molecular Medicine
2007 .01
-
Determination of curcumin in rat plasma using UPLC-MS/MS and its application to a pharmacokinetic study of a novel curcumin formulation
한국분석과학회 학술대회
2018 .11
-
Determination of curcumin in rat plasma using UPLC-MS/MS and its application to a pharmacokinetic study of a novel curcumin formulation
한국분석과학회 학술대회
2018 .11
-
Curcumin Inhibits Cell Proliferation of Human Colorectal HCT116 Cells through Up-Regulation of Activating Transcription Factor 3 (ATF3)
생명과학회지
2012 .04
-
Curcumin이 인체 유방암세포 MDA-MB-231 Cell의 전이 과정과 Matrix Metalloproteinase-9 활성에 미치는 영향
한국영양학회지
2006 .12
-
Rat Mammary Epithelial Cell Subpopulations In Vivo and In Vitro
생명과학
1993 .05
이 논문의 저자 정보
최근 본 자료
댓글(0)
0