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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 282 - 289 (8page)
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During radiotherapy of cancer, neighboring normal cells may receive sub-lethal doses of radiation. To investigate whether such low levels of radiation modulate normal cell responses to death stimuli, various doses of γ-rays. Analysis of cell viability using an exclusion dye propidium iodide revealed that the irradiation up to 10 Gy killed the fibroblasts only to a minimal extent. In contrast, the cells efficiently lost their viability when exposed to 0.5-0.65 mM H2O2. This type of cell death was accompanied by JNK activation, and was reversed by the use of a JNK-specific inhibitor SP600125. Interestingly, H2O2 failed to kill the fibroblasts when these cells were pre-irradiated, 24 h before H2O2 treatment, with 0.25-0.5 Gy of γ-rays. These cytoprotective doses of γ-rays did not enhance cellular capacity to degrade H2O2, but elevated cellular levels of p21Cip/WAF1, a p53 target that can suppress H2O2-induced cell death by blocking JNK activation. Consistently, H2O2-induced JNK activation was dramatically suppressed in the pre-irradiated cells. The overall data suggests that ionizing radiation can impart normal fibroblasts with a survival advantage against oxidative stress by blocking the process leading to JNK activation.
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참고문헌 (28)
참고문헌 신청
/ / . Signal transduction by the JNK group of MAPkinases. Cell 2000 103 : 239 ~ 52
/ / Choi E. A non-enzymatic p21protein inhibitor of stress-activated protein kinases. Nature1996 : 804 ~ 7
/ / Das DK. Molecularadaptation of vascular endothelial cells to oxidative stress.Am J Physiol 1993
/ / Grant S. MAPKpathways in radiation responses. Oncogene 2003 : 5885 ~ 96
/ / Jaattela M. Heat shockprotein 70 promotes cancer cell viability by safeguardinglysosomal integrity. Cell Cycle 2004 : 1484 ~ 5
/ / Choi E. A non-enzymatic p21protein inhibitor of stress-activated protein kinases. Nature1996 : 804 ~ 7
/ / Das DK. Molecularadaptation of vascular endothelial cells to oxidative stress.Am J Physiol 1993
/ / Grant S. MAPKpathways in radiation responses. Oncogene 2003 : 5885 ~ 96
/ / Jaattela M. Heat shockprotein 70 promotes cancer cell viability by safeguardinglysosomal integrity. Cell Cycle 2004 : 1484 ~ 5
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