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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 557 - 562 (6page)
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p21Cip/WAF1, an important regulator of cell proli-feration, is induced by both p53- and extra-celular signal regulated kinase (ERK) pathways. The induction of p21Cip/WAF1 occurs by prolonged activation of the ERKs caused by extracellular stimuli, such as zinc. However, not all the cells appeared to respond to ERK pathway dependent p21Cip/WAF1 induction. Here we investigated the cause of such diference using colorectal cancer cells. p21Cip/WAF1 induction and concomitant reduc-tion of bromodeoxyuridine (BrdU) incorporation DLD-1. However, HCT-16 cels with high end-ogenous p21Cip/WAF1 levels did not show any ad-ditional increment of p21Cip/WAF1 levels by zinc treatment and did maintain high BrdU incor-poration level. The p21Cip/WAF1 induction by zinc depended upon prolonged activation of extra-cellular signal regulated kinase (ERK) was not ob-served in HCT-116 cells. The percentage of BrdU positive cells was 50% higher in p21Cip/WAF1 -/- HCT-116 cells compared to p21Cip/WAF1 +/+ HCT- 16 cels, and no cels induced p21Cip/WAF1 in-corporated BrdU in its nucleus, yet confirming the importance of p21Cip/WAF1 induction in anti- proliferation. These results again suport that p21Cip/WAF1 induction is a determinant in the re-gulation of colonic proliferation by the ERK pathway.
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참고문헌 (26)
참고문헌 신청
/ / a potential mediator of p53 tumor suppression Cell1993 toki (t) : 817 ~ 25
/ 1995 / p21 is necessary forthe p53-mediated G1 arrest in human cancer cells : 5187 ~ 90
/ 1996 / Regulationof p21WAF1/CIP1 expression through mitogen-activatedprotein kinase signaling pathway : 31 ~ 5
/ 1997 / Butyrate activatesthe WAF1/Cip1 gene promoter through Sp1 sites in ap53-negative human colon cancer cell line toki (t) : 22199 ~ 206
/ 1997 / High-intensity Rafsignal causes cell cycle arrest mediated by p21Cip1 : 5588 ~ 97
/ 1995 / p21 is necessary forthe p53-mediated G1 arrest in human cancer cells : 5187 ~ 90
/ 1996 / Regulationof p21WAF1/CIP1 expression through mitogen-activatedprotein kinase signaling pathway : 31 ~ 5
/ 1997 / Butyrate activatesthe WAF1/Cip1 gene promoter through Sp1 sites in ap53-negative human colon cancer cell line toki (t) : 22199 ~ 206
/ 1997 / High-intensity Rafsignal causes cell cycle arrest mediated by p21Cip1 : 5588 ~ 97
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