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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 157 - 164 (8page)
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초록· 키워드
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Selenium is a dietary esential trace nutrient with important biological roles. Selenocompounds were reported to induce apoptosis in many types of tumor cells. In this study, we investigated the signaling pathway involved in the selenite-induced apoptosis using Chang liver cells as a non-malig-nant cell model. The Chang liver cell apoptosis induced by selenite (10 M) was confirmed by DNA fragmentation and typical apoptotic nuclear changes. Treatment of selenite increased intracell-ular reactive oxygen species (ROS) level and c-Jun N-terminal kinase1 (JNK1) phosphorylation. The selenite-induced cel death was attenuated by SP600125, a specific inhibitor of JNK, and by dominant negative JNK1 (DN-JNK1). Antioxidants such as glutathione (GSH), N-acetyl cysteine (NAC), curcumin, epigallocatechin gallate (EGCG) and epi-lular ROS elevation and JNK1 phosphorylation. Our results sugest that selenite-induced apopto-sis in Chang liver cells was preceded by the ROS generation and JNK1 activation.
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참고문헌 (31)
참고문헌 신청
/ 1995 / Anti-tumour and antioxidant activity of natural curcuminoids : 79 ~ 83
/ 19961957-63 / Effects of selenium supplementation forcancer prevention in patients with carcinoma of the skin Nutritional Prevention of CancerStudy Group
/ 1998 / Chemopreventive agents : 179 ~ 92
/ 1999 / Differential regulation of mitogenactivatedprotein kinases by microtubule-binding agents inhuman b
/ 1999 / Is ascorbic acid an antioxidant for the plasmamembrane : 995 ~ 1006
/ 19961957-63 / Effects of selenium supplementation forcancer prevention in patients with carcinoma of the skin Nutritional Prevention of CancerStudy Group
/ 1998 / Chemopreventive agents : 179 ~ 92
/ 1999 / Differential regulation of mitogenactivatedprotein kinases by microtubule-binding agents inhuman b
/ 1999 / Is ascorbic acid an antioxidant for the plasmamembrane : 995 ~ 1006
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