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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 335 - 342 (8page)
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Cell cycle regulating proteins are known to have close relation with the proliferation of the mammal-ian cells. In injured liver, the number of HSCs is increased from proliferation. However, the ex-pression of cell cycle proteins of HSCs during proliferation remains unevaluated. Therefore, cell cycle protein profiles of HSCs were studied in dimethyl-nitrosamine (DMN)-induced rat liver fi-brosis model. Sprague-Dawley rats were intraperi-toneally injected of DMN and the animals were sacrificed every week up to 4 weeks. HSCs were separated and the number of the cells in S phase was counted to evaluate the cell proliferation by flow cytometry. The expression of cyclin A, cyclin B, cyclin D1, cdk2, cdk4, cdc2, proliferating cell nuclear antigen (PCNA), p21 Cip/WAF1 , and p27 was examined with immunoblotting analysis. Portion of S-phase cells peaked 7days after DMN injection. At that time, cyclin A, and PCNA showed significant increase in HSCs compared to untreated HSCs (114% and 116%, respectively, P ＜0.001). p21 Cip/WAF1 was decreased significantly in DMN-treated HSCs com -pared to control cells (88%, P ＜0.001). The increase of cyclin A, and PCNA and the decrease of p21 Cip/WAF1 seem to play important roles in the proliferation of HSCs during the early period of DMN treatment.
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참고문헌 (27)
참고문헌 신청
/ / Chandrakasan G : 215 ~ 22
/ / Cyclin E and cyclin A arelikely targets of Src for PDGF-induced DNA synthesis infibroblasts 526 : 82 ~ 6
/ / Differential modulation ofG1 cyclins and the cdk Inhibitor p27kip1 by platelet-derivedgrowth factor and plasma factors in density-arrestedfibroblasts : 11253 ~ 60
/ / Inhibitory effect ofoestradiol on activation of rat hepatic stellate cells in vivo andin vitro 44 : 127 ~ 36
/ / Involvement of phoshatidylinositol3-kinase in the activation of extracellularsignal-regulated kinase by PDGF in hepatic stellate cells : 141 ~ 5
/ / Cyclin E and cyclin A arelikely targets of Src for PDGF-induced DNA synthesis infibroblasts 526 : 82 ~ 6
/ / Differential modulation ofG1 cyclins and the cdk Inhibitor p27kip1 by platelet-derivedgrowth factor and plasma factors in density-arrestedfibroblasts : 11253 ~ 60
/ / Inhibitory effect ofoestradiol on activation of rat hepatic stellate cells in vivo andin vitro 44 : 127 ~ 36
/ / Involvement of phoshatidylinositol3-kinase in the activation of extracellularsignal-regulated kinase by PDGF in hepatic stellate cells : 141 ~ 5
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