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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2012.1
- 수록면
- 448 - 456 (9page)
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초록· 키워드
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Parthenolide (PT), a sesquiterpene lactone derived from the plant feverfew, has pro-apoptotic activity in a number of cancer cell types. We assessed whether PT induces the apoptosis of hepatic stellate cells (HCSs)and examined its effects on hepatic fibrosis in an in vivo model. The effects of PT on rat HSCs were investigated in relation to cell growth inhibition, apoptosis, NF-κB binding activity, intracellular reactive oxygen species (ROS) generation, and glutathione (GSH) levels. In addition,the anti-fibrotic effects of PT were investigated in a thioacetamide-treated rat model. PT induced growth inhibition and apoptosis in HSCs, as evidenced by cell growth inhibition and apoptosis assays. PT increased the expression of Bax proteins during apoptosis,but decreased the expression of Bcl-2 and Bcl-XL proteins. PT also induced a reduction in mitochondrial membrane potential, poly(ADP-ribose) polymerase cleavage, and caspase-3 activation. PT inhibited TNF-α-stimulated NF-κB binding activity in HSCs. The pro-apoptotic activity of PT in HSCs was associated with increased intracellular oxidative stress as evidenced by increased intracellular ROS levels and depleted intracellular GSH levels. Furthermore, PT ameliorated hepatic fibrosis significantly in a thioacetamide-treated rat model. In conclusion, PT exhibited pro-apoptotic effects in rat HSCs and ameliorated hepatic fibrosis in a thioacetamide-induced rat model.
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참고문헌 (23)
참고문헌 신청
Arthur MJ / 2002 / Reversibility of liver fibrosis and cirrhosis following treatment for hepatitis C / Gastroenterology 122 : 1525 ~ 1528
Elsharkawy AM / 2005 / The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis / Apoptosis 10 : 927 ~ 939
Friedman SL / 2000 / Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury / J Biol Chem 275 : 2247 ~ 2250
Habens F / 2005 / Novel sulfasalazine analogues with enhanced NF-κB inhibitory and apoptosis promoting activity / Apoptosis 10 : 481 ~ 491
Hehner SP / 1998 / Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa-beta / J Biol Chem 273 :
Elsharkawy AM / 2005 / The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis / Apoptosis 10 : 927 ~ 939
Friedman SL / 2000 / Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury / J Biol Chem 275 : 2247 ~ 2250
Habens F / 2005 / Novel sulfasalazine analogues with enhanced NF-κB inhibitory and apoptosis promoting activity / Apoptosis 10 : 481 ~ 491
Hehner SP / 1998 / Sesquiterpene lactones specifically inhibit activation of NF-kappa B by preventing the degradation of I kappa B-alpha and I kappa-beta / J Biol Chem 273 :
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