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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 524 - 532 (9page)
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초록· 키워드
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Receptor activator of NFκB ligand (RANKL) is known as a key regulator of osteoclastogenesis. However, the fact that fibroblasts and periodontal ligament cells express RANKL in response to bacterial sub-stances, suggests that RANKL may have evolved as a part of the immunity to infection. As RANKL increases the survival and activity of dendritic cells, it may have similar effects on macrophages. To address this issue, we studied the effect of RANKL on various functions of macrophages using mouse bone marrow derived macrophages. RANKL en-ated the expression of CD86. RANKL-treated macro-phages showed increased allogeneic T cell acti-vation and phagocytic activity compared to control cells. In addition, RANKL increased the expression of TNFα, MCP-1, and IL-6 but not of IL-10, IL-12, IFN-γ, and iNOS. Colectively, RANKL augmented the activity of macrophages especially as antigen presenting cells, suggesting its new role in immune regulation.
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참고문헌 (26)
참고문헌 신청
/ / Comparison of multinucleatedcells elicited in rats by particulate bone : 327 ~ 31
/ / Multinucleated cellselicited in response to implants of devitalized bone particlespossess receptors for calcitonin : 117 ~ 20
/ / Origin of osteoclasts mature monocytes and macrophages are capable ofdifferentiating into osteoclasts under a suitable microenvironmentprepared by bone marrow-derived st
/ 1000 / Celladhesion is a prerequisite for osteoclast survival 270 : 550 ~ 6
/ 1995 / In vitrodifferentiation of the murine macrophage cell line BDM-1 intoosteoclast-like cells 136 : 4285 ~ 92
/ / Multinucleated cellselicited in response to implants of devitalized bone particlespossess receptors for calcitonin : 117 ~ 20
/ / Origin of osteoclasts mature monocytes and macrophages are capable ofdifferentiating into osteoclasts under a suitable microenvironmentprepared by bone marrow-derived st
/ 1000 / Celladhesion is a prerequisite for osteoclast survival 270 : 550 ~ 6
/ 1995 / In vitrodifferentiation of the murine macrophage cell line BDM-1 intoosteoclast-like cells 136 : 4285 ~ 92
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